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Postion:Product Catalog >API>Hormones and the Endocrine System>Contraceptives>Chlormadinone acetate
Chlormadinone acetate
  • Chlormadinone acetate

Chlormadinone acetate

Price $1
Package 1g
Min. Order: 1g
Supply Ability: 200kg
Update Time: 2020-01-09

Product Details

Product Name: Chlormadinone acetate CAS No.: 302-22-7
Min. Order: 1g Purity: 99%
Supply Ability: 200kg Release date: 2020/01/09

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Product Name:
Chlormadinone acetate
Synonyms:
6-chloro-17-alpha-acetoxy-4,6-pregnadiene-3,20-dione;6-Chloro-17alpha-acetoxy-4,6-pregnadiene-3,20-dione;6-chloro-17-alpha-hydroxy-delta(sup6)-progesteroneacetate;6-Chloro-17alpha-hydroxy-delta6-progesterone acetate;6-Chloro-17alpha-hydroxypregna-4,6-diene-3,20-dione acetate;6-chloro-17-alpha-hydroxypregna-4,6-diene-3,20-dioneacetate;6-Chloro-17-hydroxypregna-4,6-diene-3,20-dione acetate;6-Chloro-3,20-dioxopregna-4,6-dien-17-yl acetate
CAS:
302-22-7
MF:
C23H29ClO4
MW:
404.93
EINECS:
206-118-0
Product Categories:
Intermediates & Fine Chemicals;Pharmaceuticals;Steroids;Steroid and Hormone;SUICALM
Mol File:
302-22-7.mol
Article illustration
 
Chlormadinone acetate Chemical Properties
Melting point 
212°C
alpha 
D +6° (c = 1 in CHCl3)
Boiling point 
512.5±50.0 °C(Predicted)
density 
1.1345 (estimate)
storage temp. 
-20°C Freezer
form 
neat
λmax
285nm(EtOH)(lit.)
Merck 
14,2102
BRN 
2633614
NIST Chemistry Reference
Chlormadinone acetate(302-22-7)
EPA Substance Registry System
Pregna-4,6-diene-3,20-dione, 17-(acetyloxy)-6-chloro- (302-22-7)
 
Safety Information
Hazard Codes 
T
Risk Statements 
60-61-40-48
Safety Statements 
53-22-36/37/39-45
WGK Germany 
3
RTECS 
TU3750000
HS Code 
29372390
Hazardous Substances Data
302-22-7(Hazardous Substances Data)
MSDS Information
Provider
Language
SigmaAldrich
English
 
Chlormadinone acetate Usage And Synthesis
Chemical Properties
Crystalline Solid
Uses
Orally active progesteron with antiandrogenic activity; has been used in combinations as an oral contraceptive. Progestogen; antineoplastic (hormonal)
Uses
tranquilizer, neuroleptic, alpha adrenergic blocker
Brand name
Gestafortin;Luteran;Ovosiston.
World Health Organization (WHO)
Chlormadinone acetate, a synthetic progestogen, was introduced in 1965 as a component in oral contraceptive preparations. In 1967, as a result of new regulations required by the United States Food and Drug Administration, chlormadinone acetate was submitted to long-term toxicity studies and by the early 1970s it was shown to be associated with an increased incidence of mammary tumours in beagle bitches which led to its withdrawal by several regulatory authorities. Subsequently the validity of the beagle bitch model as a predictor of carcinogenicity of steroid contraceptives has been contested by many national regulatory authorities and chlormadinone remains available in some countries for contraceptive purposes. In some instances it is indicated for treatment of progesterone deficiency and endometriosis, and of irregular uterine bleeding due to fibroids. (Reference: (WHODI) WHO Drug Information, 84.1, 5, 1984)
Safety Profile
Suspected carcinogen with experimental carcinogenic and tumorigenic data. Moderately toxic by intraperitoneal route. Human maternal and reproductive effects by ingestion, intramuscular, and possibly other routes: ovary, uterus, cervix, vagina, and fallopian tube changes; menstrual cycle changes or disorders; changes in ferthty; and other unspecified female effects. A human teratogen that causes developmental abnormalities of the endocrine system in the fetus. Experimental teratogenic and reproductive effects. An oral contraceptive. When heated to decomposition it emits toxic fumes of Cl-.
 
Chlormadinone acetate Preparation Products And Raw materials
 
 
 

Company Profile Introduction

Established in 2014,Career Henan Chemical Co. is a manufacturerspecializing in the sale of fine chemicals. Mainly deals in the sales of: Pharmaceutical intermediates OLED intermediates: Pharmaceutical intermediates; OLED intermediates;

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