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Postion:Product Catalog >Biochemical Engineering>Biochemical Reagents>Agonist Inhibitors>FTI-277 trifluoroacetate salt
FTI-277 trifluoroacetate salt
  • FTI-277 trifluoroacetate salt
  • FTI-277 trifluoroacetate salt
  • FTI-277 trifluoroacetate salt

FTI-277 trifluoroacetate salt

Price $1
Package 1g
Min. Order: 1g
Supply Ability: 200kg
Update Time: 2020-01-10

Product Details

Product Name: FTI-277 trifluoroacetate salt CAS No.: 170006-73-2
Min. Order: 1g Purity: 99%
Supply Ability: 200kg Release date: 2020/01/10

Mary

 

Names

Name
FTI-277 trifluoroacetate salt
Synonym
More Synonyms

 FTI-277 Biological Activity

Description
FTI-277 is an inhibitor of farnesyl transferase (FTase); a highly potent Ras CAAX peptidomimetic which antagonizes both H- and K-Ras oncogenic signaling.IC50 value:Target: FTase inhibitorin vitro: Treatment with FTI-277 (20 microM) for 48 h prior to irradiation led to a significant decrease in survival of radioresistant cells expressing the 24-kDa isoform (HeLa 3A) but had no effect on the survival of control cells (HeLa PINA). The radiosensitizing effect of FTI-277 is accompanied by a stimulation of postmitotic cell death in HeLa 3A cells and by a reduction in G(2)/M-phase arrest in both cell types [1]. Treatment of PC-3 cells with GGTI-298 and FTI-277 inhibited migration and invasion in a time- and dose-dependent manner [3].in vivo: FTI-277 treatment prevented increased PTP-1B and PTEN protein expression in burned mice as compared with vehicle alone. In contrast, FTI-277 did not significantly alter protein expression of PTP-1B and PTEN in sham-burned mice [2].
Related Catalog
Signaling Pathways >> Metabolic Enzyme/Protease >> Farnesyl Transferase
Research Areas >> Cancer
References

[1]. Cohen-Jonathan E, et al. The farnesyltransferase inhibitor FTI-277 suppresses the 24-kDa FGF2-induced radioresistance in HeLa cells expressing wild-type RAS. Radiat Res. 1999 Oct;152(4):404-11.

[2]. Nakazawa H, et al. Role of protein farnesylation in burn-induced metabolic derangements and insulin resistance in mouse skeletal muscle. PLoS One. 2015 Jan 16;10(1):e0116633.

[3]. Virtanen SS, et al. Inhibition of GGTase-I and FTase disrupts cytoskeletal organization of human PC-3 prostate cancer cells. Cell Biol Int. 2010 Aug;34(8):815-26.

 Chemical & Physical Properties

Molecular Formula
C22H29N3O3S2
Molecular Weight
447.61
PSA
194.85000
LogP
4.84460

 Safety Information

Hazard Codes
Xi: Irritant;
Risk Phrases
R36/37/38
Safety Phrases
S26

 Synonyms

fti-277
 

Company Profile Introduction

Established in 2014,Career Henan Chemical Co. is a manufacturerspecializing in the sale of fine chemicals. Mainly deals in the sales of: Pharmaceutical intermediates OLED intermediates: Pharmaceutical intermediates; OLED intermediates;

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