8-Aminoadenosine NEW
| Price | $62 |
| Package | 2mg |
| Supply Ability: | 10g |
| Update Time: | 2025-07-17 |
Product Details
| Product Name: 8-Aminoadenosine | CAS No.: 3868-33-5 |
| Supply Ability: 10g | Release date: 2025/07/17 |
Product Introduction
Bioactivity
| Name | 8-Aminoadenosine |
| Description | 8-Aminoadenosine (8-NH2-Ado) is an RNA-directed nucleoside analogue that effectively diminishes cellular ATP levels and impedes mRNA synthesis. It also obstructs Akt/mTOR signaling, inducing autophagy and apoptosis in a p53-independent manner. Its significant antitumor activity underscores its therapeutic potential. |
| In vitro | 8-Aminoadenosine (8-NH2-Ado) demonstrates a range of bioactive effects across various cell lines. In MM.1S and U266 cells, it exhibits half-maximal inhibitory concentrations (IC50s) of 1.5 μM and 8.88 μM, respectively, after a 48-hour exposure[1]. At a concentration of 10 μM over 24 hours, it induces significant apoptotic death of MCF-7 cells through a p53-independent mechanism, characterized by PARP cleavage[2]. Additionally, at a concentration of 3 μM, 8-Aminoadenosine triggers autophagy in MM.1S cells within 0.5 to 4 hours, and notably reduces ATP levels and glucose consumption over similar durations[1]. This compound also causes a marked time-dependent decrease in GLUT1 expression initially, with subsequent down-regulation of both GLUT1 and GLUT4 transporters over a longer period (24 hours)[1]. It is observed to inhibit cell proliferation and induce cell death without activating p53 pathway targets or increasing p53 or p21 proteins. Its toxicological actions are adenosine kinase activity-dependent, requiring conversion to 8-NH2-ATP in specifically adenosine kinase-deficient cells[1]. Analysis of cell viability and apoptosis under various concentrations and timeframes further corroborates its impact on cell survival and apoptotic pathways[1][2]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | 8Aminoadenosine | 8-Aminoadenosine | 8 Aminoadenosine |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, USA
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