Brevilin A
| Price | $9.8 |
| Package | 1KG |
| Min. Order: | 1g |
| Supply Ability: | 20 tons |
| Update Time: | 2020-02-11 |
Product Details
| Product Name: Brevilin A | CAS No.: 16503-32-5 |
| Min. Order: 1g | Purity: ＞98% |
| Supply Ability: 20 tons | Release date: 2020/02/11 |
| Storage:: Keep away from heat， sparks and flames | Package：: Bottle / Drum / Bag |
| Delivery Time:: Prompt | Port:: Shanghai， Tianjin or Qingdao |
| Transportation:: By sea， express， air，railway | Product No. :: Jessie |
Jessie 808
Email: jessie@coreychem.com
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[Product Specification]
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Name
Brevilin A
Synonym
More Synonyms
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Description
Brevilin A is a sesquiterpene lactone isolated from Centipeda minima with anti-tumor activity. Brevilin A is a selective inhibitor of JAK-STAT signal pathway by attenuating the JAKs activity and blocking STAT3 signaling (IC50 =?10.6 µM) in Cancer Cells. Brevilin A induces apoptosis and autophagy via mitochondrial pathway and PI3K/AKT/mTOR inactivation in colon adenocarcinoma cell CT26[1][2].
Related Catalog
Signaling Pathways >> Stem Cell/Wnt >> STAT
Signaling Pathways >> Apoptosis >> Apoptosis
Research Areas >> Cancer
Signaling Pathways >> JAK/STAT Signaling >> JAK
Signaling Pathways >> Epigenetics >> JAK
Signaling Pathways >> Stem Cell/Wnt >> JAK
Signaling Pathways >> JAK/STAT Signaling >> STAT
Signaling Pathways >> Autophagy >> Autophagy
Target
IC50: 10.6 µM (STAT3 signaling)[1]
References
[1]. Chen X, et al. Brevilin A, a novel natural product, inhibits janus kinase activity and blocks STAT3 signaling in cancer cells. PLoS One. 2013 May 21;8(5):e63697.
[2]. You P, et al. Brevilin A induces apoptosis and autophagy of colon adenocarcinoma cell CT26 via mitochondrial pathway and PI3K/AKT/mTOR inactivation. Biomed Pharmacother. 2018 Feb;98:619-625.
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Density
1.2±0.1 g/cm3
Boiling Point
494.0±45.0 °C at 760 mmHg
Molecular Formula
C20H26O5
Molecular Weight
346.417
Flash Point
216.0±28.8 °C
Exact Mass
346.178009
PSA
69.67000
LogP
2.98
Vapour Pressure
0.0±1.3 mmHg at 25°C
Index of Refraction
1.535
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(3S,3aR,4S,4aR,7aR,8R,9aR)-3,4a,8-Trimethyl-2,5-dioxo-2,3,3a,4,4a,5,7a,8,9,9a-decahydroazuleno[6,5-b]furan-4-yl (2Z)-2-methyl-2-butenoate
2-Butenoic acid, 2-methyl-, (3S,3aR,4S,4aR,7aR,8R,9aR)-2,3,3a,4,4a,5,7a,8,9,9a-decahydro-3,4a,8-trimethyl-2,5-dioxoazuleno[6,5-b]furan-4-yl ester, (2Z)-
Company Profile Introduction
Established in 2014,Career Henan Chemical Co. is a manufacturerspecializing in the sale of fine chemicals.
Mainly deals in the sales of:
Pharmaceutical intermediates
OLED intermediates：
Pharmaceutical intermediates;
OLED intermediates;
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