一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

Welcome to chemicalbook!
+1 (818) 612-2111
RFQ
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

RFQ
skype
MY Account
Top
Postion:Product Catalog >API>Antipyretic analgesics>Nonsteroidal Anti-Inflammatory Drugs (NSAIDS)>Diflunisal
Diflunisal
  • Diflunisal
  • Diflunisal
  • Diflunisal
  • Diflunisal
  • Diflunisal

Diflunisal

Price $9.8
Package 1KG
Min. Order: 1g
Supply Ability: 20 tons
Update Time: 2020-02-11

Product Details

Product Name: Diflunisal CAS No.: 22494-42-4
Min. Order: 1g Purity: >98%
Supply Ability: 20 tons Release date: 2020/02/11
Storage:: Keep away from heat, sparks and flames Package:: Bottle / Drum / Bag
Delivery Time:: Prompt Port:: Shanghai, Tianjin or Qingdao
Transportation:: By sea, express, air,railway Product No. :: Jessie

Jessie  808

Email: jessie@coreychem.com

Welcome to consult us!

[Product Specification]

Names

Name
diflunisal
Synonym
More Synonyms

 Diflunisal Biological Activity

Description
Diflunisal (MK-647) is a salicylate derivative with nonsteroidal anti-inflammatory and uricosuric properties, which is used alone as an analgesic and in rheumatoid arthritis patients. The mechanism of action of diflunisal is as a Cyclooxygenase (COX) Inhibitor.
Related Catalog
Research Areas >> Inflammation/Immunology
Target

COX

In Vivo
Administration of increasing doses of Diflunisal to rats shows that the effect of the dose on the pharmacokinetics of Diflunisal is quite complicated. The plasma concentrations of Diflunisal decline exponentially with time, albeit with a half-life that increases with increasing dose. The CLP is reduced considerably when the dose increases from 3 to 10 mg/kg and then remains relatively constant over the dose range of 10 to 60 mg/kg. Diflunisal has been shown to be highly bound to rat plasma protein and dependent on concentration. The fraction of unbound Diflunisal is increased about 10-fold over the concentration range of 5 to 300 μg/mL[1]. Diflunisal exhibits activity after oral administration with potency about 25 times greater than that of aspirin, about 3 times that of glafenine and twice that of zomepirac[2].
Animal Admin
Rats[1] For the study of dose dependency, Diflunisal is administered by i.a. injection in doses of 3, 10, 30 and 60 mg/kg (1.5, 5, 15 and 30 mg/mL dosing solution in 0.1 M NaHCO3). The infusion studies consist of a bolus injection of Diflunisal followed immediately by a 7-hr infusion at a constant rate. Seven groups of rats are included in the infusion studies. The loading doses used are 2, 3, 5, 10, 25, 50 and 80 mg/kg and their corresponding infusion rates are 3, 4.5, 9, 18, 36, 72 and 144 μg/min (0.576 mL/hr of seven different dosing solutions: 0.31, 0.47, 0.94, 1.88, 3.75, 7.5 and 15 mg/mL in 0.1 M NaHCO3). Blood samples are collected serially at appropriate times for the dose-dependency studies, but collected hourly for the infusion studies. Plasma is obtained immediately by centrifugation of blood samples and extracted with acetonitrile and then frozen (-20°C) until assay[1].
References

[1]. Lin JH, et al. Dose-dependent pharmacokinetics of diflunisal in rats: dual effects of protein binding and metabolism. J Pharmacol Exp Ther. 1985 Nov;235(2):402-6.

[2]. Winter CA, et al. Analgesic activity of diflunisal [MK-647; 5-(2,4-difluorophenyl)salicylic acid] in rats with hyperalgesia induced by Freund's adjuvant. J Pharmacol Exp Ther. 1979 Dec;211(3):678-85.

[3]. Cappon GD, et al. Relationship between cyclooxygenase 1 and 2 selective inhibitors and fetal development when administered to rats and rabbits during the sensitive periods for heart development and midline closure. Birth Defects Res B Dev Reprod Toxicol. 2003 Feb;68(1):47-56.

 Chemical & Physical Properties

Density
1.4±0.1 g/cm3
Boiling Point
386.9±42.0 °C at 760 mmHg
Melting Point
32-36 °C
Molecular Formula
C13H8F2O3
Molecular Weight
250.198
Flash Point
187.8±27.9 °C
Exact Mass
250.044144
PSA
57.53000
LogP
4.44
Vapour Pressure
0.0±0.9 mmHg at 25°C
Index of Refraction
1.601
Storage condition
Refrigerator
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 

Company Profile Introduction

Established in 2014,Career Henan Chemical Co. is a manufacturerspecializing in the sale of fine chemicals. Mainly deals in the sales of: Pharmaceutical intermediates OLED intermediates: Pharmaceutical intermediates; OLED intermediates;

You may like

Recommended supplier

Product name Price   Suppliers Update time
$30.00
VIP6Y
TargetMol Chemicals Inc.
2026-06-02
$30.00
VIP4Y
TargetMol Chemicals Inc.
2026-06-02
$30.00
VIP2Y
TargetMol Chemicals Inc.
2026-06-02
VIP2Y
Shaanxi Dideu New Materials Co. Ltd
2025-12-24
Hebei Yanxi Chemical Co., Ltd.
2025-06-20
$10.00
Shandong Xuhuang New material CoLTD
2025-03-21
$666.70
Baoji Guokang Healthchem co.,ltd
2021-11-02
$1.00
Cangzhou Wanyou New Material Technology Co.,Ltd
2019-08-02
$30.00
VIP2Y
TargetMol Chemicals Inc.
2025-05-01
  • Since: 2014-12-17
  • Address: 702, Building 10, East District, National University Science and Technology Park, High tech Zone, Zh
INQUIRY
天祝| 峨边| 九寨沟县| 荔波县| 泰州市| 城固县| 天长市| 梁平县| 祁连县| 福安市| 阿瓦提县| 商都县| 万安县| 广饶县| 彭泽县| 临武县| 大埔县| 和硕县| 太仓市| 太谷县| 峨边| 新竹市| 台南市| 凤冈县| 临邑县| 金堂县| 苏州市| 鄂托克旗| 恭城| 藁城市| 周至县| 华阴市| 虞城县| 光山县| 东光县| 比如县| 凤台县| 桦南县| 汉源县| 天镇县| 远安县|