Product Name: CYCLOMETHICONE 4 (200 MG)

Synonyms: CYCLOMETHICONE 4 (200 MG);Cyclicdimethylpolysiloxane;cyclopolydimethylsiloxane;q2-1401;dowcorning344fluid;dowcorningx2-1401;sws03314;sws-f222

CAS: 69430-24-6

MF:

MW: 0

EINECS:

Product Categories: UVCBs-organic

Mol File: Mol File

CYCLOMETHICONE 4 (200  MG) Structure

CYCLOMETHICONE 4 (200 MG) Chemical Properties

EPA Substance Registry System Cyclomethicone (69430-24-6)

Safety Information

RIDADR 1993

HazardClass 3.2

PackingGroup III

MSDS Information

CYCLOMETHICONE 4 (200 MG) Usage And Synthesis

Chemical Properties Cyclomethicone occurs as a clear, colorless and tasteless volatile liquid.

Uses Pharmaceutic aid (wetting agent).

Production Methods Cyclomethicone is manufactured by the distillation of crude polydimethylsiloxanes.

Brand name VS-7158 (Witco); VS-7207 (Witco); VS-7349 (Witco).

Pharmaceutical Applications Cyclomethicone is mainly used in topical pharmaceutical and cosmetic formulations such as water-in-oil creams.

Cyclomethicone has been used in cosmetic formulations, at concentrations of 0.1-50%, since the late 1970s and is now the most widely used silicone in the cosmetics industry. Its high volatility, and mild solvent properties, make it ideal for use in topical formulations because its low heat of vaporization means that when applied to skin it has a ‘dry’ feel.

Safety Cyclomethicone is generally regarded as a relatively nontoxic and nonirritant material. Although it has been used in oral pharmaceutical applications, cyclomethicone is mainly used in topical pharmaceutical formulations. It is also widely used in cosmetics. Studies of the animal and human toxicology of cyclomethicone suggest that it is nonirritant and not absorbed through the skin. Only small amounts are absorbed orally; an acute oral dose in rats produced no deaths.

storage Cyclomethicone should be stored in an airtight container in a cool, dry, place.

Regulatory Status Included in the FDA Inactive Ingredients Database(oral powderfor reconstitution, topical lotion, topical cream, topical emulsion). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.