Robinin NEW
| Price | $68 | $163 | $243 |
| Package | 1mg | 5mg | 10mg |
| Supply Ability: | 10g |
| Update Time: | 2026-07-27 |
Product Details
| Product Name: Robinin | CAS No.: 301-19-9 |
| Purity: 99.96% | Supply Ability: 10g |
| Release date: 2026/07/27 |
Product Introduction
Bioactivity
| Name | Robinin |
| Description | Robinin (NSC-9222) belongs to natural products, serving as a TLR2 inhibitor with cell permeability. Robinin exerts anti-inflammatory and antitumor activities through inhibiting the TLR2-PI3K-AKT pathway, and can be used for experimental research related to pancreatic cancer. |
| In vitro | Methods: Mouse primary chondrocytes were used. After 12 h treatment with IL-1β (10 ng/mL) to establish an injury model, cells were incubated with 10 μg/mL Robinin for 24 h. Results: CCK-8 and flow cytometry showed that Robinin reversed the IL-1β-induced decrease in cell viability and inhibited apoptosis; Western blot further confirmed its protective effects by upregulating Bcl-2 and downregulating Bax and cleaved-caspase3 expression. [1] Methods: H9c2 rat cardiomyocytes were used. Cells were pre-treated with 50 μM Robinin for 24 h, followed by addition of 40 μM H?O? or 5 μM doxorubicin to induce injury. Results: MTT, AO/EB, and Hoechst staining showed that Robinin increased cell viability and reduced apoptosis; DCFH-DA and flow cytometry demonstrated its reduction of reactive oxygen species levels, enhancement of antioxidant enzyme activity, and inhibition of endoplasmic reticulum stress-related gene and protein expression. [2] |
| In vivo | Methods: In a hypercholesterolemic rat model, 2% cholesterol diet was used to induce hypercholesterolemia for 8 weeks. Starting from week 6, Robinin (50 mg/kg, once every two days, dissolved in DMSO; control received vehicle) was administered by intraperitoneal injection for 2 consecutive weeks, followed by ex vivo cardiac ischemia-reperfusion injury. Results: Robinin improved cardiac function, inhibited mitochondrial permeability transition pore opening, attenuated myocardial histopathological damage, upregulated myocardial Akt, Nrf2, HO-1, and NQO1 expression, and downregulated GSK3β and Fyn levels.[3] |
| Storage | Keep away from moisture,Keep away from direct sunlight, Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | Pyridine, Methanol, etc. : Soluble Ethanol : Soluble 10% DMSO+40% PEG300+5% Tween-80+45% Saline : 3.3 mg/mL (4.46 mM), Sonication is recommended. DMSO : 100 mg/mL (135.01 mM), Sonication is recommended. |
| Keywords | Toll-like Receptor (TLR) | TLR | Robinin | Oxidized | NSC-9222 | NSC9222 | NF-κB | LDL | Inhibitor | inhibit | Inflammatory | hPBMCs |
| Inhibitors Related | Stavudine | Aceglutamide | Adenosine | Urea | Tamoxifen | Hydroxychloroquine | Metronidazole | Formamide | Dimethyl phthalate | Alginic acid | Dextran sulfate sodium salt (MW 5000) | Sildenafil citrate |
| Related Compound Libraries | Polyphenolic Natural Product Library | Bioactive Compound Library | Traditional Chinese Medicine Monomer Library | Membrane Protein-targeted Compound Library | Selected Plant-Sourced Compound Library | Natural Product Library | Miao medicine Compound Library | Saccharide and Glycoside Natural Product Library | Anti-Inflammatory Traditional Chinese Medicine Compound Library | Anti-infective Natural Product Library | Bioactive Compounds Library Max | Anti-Cancer Active Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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