A-77636 NEW
| Price | $1520 | $1980 | $2500 |
| Package | 25mg | 50mg | 100mg |
| Supply Ability: | 10g |
| Update Time: | 2026-05-11 |
Product Details
| Product Name: A-77636 | CAS No.: 778546-51-3 |
| Supply Ability: 10g | Release date: 2026/05/11 |
Product Introduction
Bioactivity
| Name | A-77636 |
| Description | A-77636 is a potent, selective, and long-acting oral dopamine D1 receptor agonist with an effective concentration (EC50) of 1.1 nM and a corresponding pEC50 value of 8.13. It demonstrates the highest affinity for the dopamine D1 receptor with a dissociation constant (Ki) of 39.8 nM and a pKi of 7.40 ± 0.09. Notably, A-77636 exhibits antiparkinsonian activity [1]. |
| In vivo | A-77636 (0-3.2 μmol/kg, subcutaneous injection) induced rotational behavior in rats with 6-OHDA lesions (ED50 = 0.32 μmol/kg sc) [1], attenuated drug-induced locomotor activity in a dose-dependent manner (1-10 mg/kg) [2], and elicited forelimb clonus in rats (ED50 = 12.3 μmol/kg s.c.) and mice (ED50 = 12.1 μmol/kg s.c.) [1]. In MPTP-treated marmosets, A-77636 (0.5, 1.0, or 2.0 μmol/kg, oral administration) increased motor activity and reduced Parkinsonian symptoms, demonstrating efficacy with both subcutaneous and oral administration [1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | DopamineReceptor | Dopamine Receptor |
| Inhibitors Related | Trifluoperazine dihydrochloride | Clozapine N-Oxide | Mirtazapine | Hexamethonium Bromide | Butyrophenone | Octopamine hydrochloride | L-DOPA | Creatine | Dopamine hydrochloride | Oxolinic acid | Mianserin hydrochloride | Doxepin hydrochloride |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
You may like
Recommended supplier
| Product name | Price | Suppliers | Update time | |
|---|---|---|---|---|
| $97.00 |
VIP6Y
|
TargetMol Chemicals Inc.
|
2026-06-02 | |
|
VIP2Y
|
Shaanxi Xianhe Biotech Co., Ltd
|
2026-06-23 | ||
|
VIP2Y
|
Shenzhen Nexcon Pharmatechs Ltd.
|
2026-07-01 |
United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
INQUIRY