A2A receptor antagonist 3 NEW
| Price | $1620 | $2580 |
| Package | 25mg | 50mg |
| Supply Ability: | 10g |
| Update Time: | 2026-07-17 |
Product Details
| Product Name: A2A receptor antagonist 3 | CAS No.: 2738606-83-0 |
| Purity: 99.58% | Supply Ability: 10g |
| Release date: 2026/07/17 |
Product Introduction
Bioactivity
| Name | A2A receptor antagonist 3 |
| Description | A2A receptor antagonist 3 (Example 92) is an adenosine A2a receptor antagonist (Ki: 0.4 nM). receptor (Ki: 1467 nM). |
| In vitro | Method: Membranes from CHO cells expressing human adenosine A1, A2A, A2B, or A3 receptors were tested in a 384-well TR-FRET competitive binding assay at room temperature. The assay contained 1× LabMed buffer, 100 μg/mL saponin, 1% DMSO, and 0.02% Pluronic. Fluorescent ligand CA200645 was used at 30 nM for A2B and 100 nM for A1, A2A, and A3 receptors. After 2 h, fluorescence was measured at 620 and 665 nm after excitation at 337 nm. Result: A2A receptor antagonist 3 bound the human A2A receptor with Ki=0.4 nM. Ki values at human A2B, A1, and A3 receptors were 37, 107, and 1467 nM, respectively, showing highest affinity for A2A.[1] Method: PBMCs isolated from sodium-citrated blood from healthy human donors by Histopaque separation were plated at 50,000 cells/well on plates coated with anti-CD3 at 1 μg/mL. Anti-CD28, 1 μg/mL, NECA, 1 μM, and antagonist concentrations of 0.003–10 μM were added. After 24 h at 37°C, supernatant IL-2 was quantified using an MSD assay. Result: The compound reversed NECA-mediated suppression of T-cell IL-2 production with a functional IC50 of 0.004 μM.[1] Method: Heparinized human whole blood was incubated with serial concentrations of antagonist and rolipram for 20 min at 37°C, followed by stimulation with NECA, 3 μM, for 60 min. Samples were fixed and lysed, stained with Alexa Fluor 488 anti-phospho-CREB and Alexa Fluor 647 anti-CD8 antibodies, and analyzed by flow cytometry. Result: In human CD8+ T cells, the compound inhibited the NECA-induced phospho-CREB response with a functional IC50 of 0.02 μM.[1] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 20 mg/mL (44 mM), Sonication is recommended. |
| Inhibitors Related | Xanthine | Theophylline monohydrate | Fostamatinib | Diphylline | Acefylline | CPI-444 | Sulcatone | Adenosine 5'-monophosphate monohydrate | Inosine | Theobromine | Adenosine 5'-monophosphate disodium salt | Doxofylline |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
You may like
Recommended supplier
| Product name | Price | Suppliers | Update time | |
|---|---|---|---|---|
| $56.00 |
VIP6Y
|
TargetMol Chemicals Inc.
|
2026-07-20 | |
| $48.00 |
VIP4Y
|
TargetMol Chemicals Inc.
|
2026-07-14 | |
|
VIP2Y
|
Shaanxi Dideu New Materials Co. Ltd
|
2026-07-16 |
United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
INQUIRY