Product Details
| Product Name:
ABT-100 |
CAS No.:
450839-40-4 |
| Supply Ability:
10g |
Release date:
2026/05/11 |
Product Introduction
Bioactivity
| Name | ABT-100 |
| Description | ABT-100 is a potent, highly selective, and orally active inhibitor of farnesyl transferase [farnesyl-protein transferase] with broad-spectrum antitumor activity. |
| Cell Research | Cell Line: EJ-1, DLD-1, MDA-MB-231, HCT-116, MiaPaCa-2, PC-3, and DU-145 cells. Concentration: 0.1-100 nM. Incubation Time: 7 days |
| Animal Research | Animal Model: C.B-17 scid male mice with EJ-1 cells. Dosage: 6.25 mg/kg/day, 12.5 mg/kg/day. Administration: Subcutaneous injection; daily; for 21 days |
| In vitro | ABT-100 (0.1-100 nM; 7 days; EJ-1, DLD-1, MDA-MB-231, HCT-116, MiaPaCa-2, PC-3, and DU-145 cells) treatment shows dose-dependent growth inhibition of human cancer cell lines. It also inhibits colony formation at concentrations comparable with which ABT-100 inhibits anchorage-dependent growth. ABT-100 inhibits cell proliferation (IC50s of 2.2 nM, 3.8 nM, 5.9 nM, 6.9 nM, 9.2 nM, 70 nM and 818 nM for EJ-1, DLD-1, MDA-MB-231, HCT-116, MiaPaCa-2, PC-3, and DU-145 cells, respectively), increases apoptosis and decreases angiogenesis. |
| In vivo | ABT-100 (6.25-12.5 mg/kg/day; subcutaneous injection; daily; for 21 days; C.B-17 scid male mice) treatment induces regression of EJ-1 tumors in mice. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | ABT-100 | ABT100 | ABT 100 |
| Inhibitors Related | Stavudine | Aceglutamide | Urea | Tamoxifen | Cysteamine hydrochloride | D(+)-Raffinose pentahydrate | Metronidazole | Citric Acid Triammonium | Formamide | Dimethyl phthalate | Alginic acid | Sildenafil citrate |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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