Product Details
| Product Name:
ABT-107 |
CAS No.:
855291-54-2 |
| Supply Ability:
10g |
Release date:
2026/04/22 |
Product Introduction
Bioactivity
| Name | ABT-107 |
| Description | ABT-107, a selective α7 neuronal nicotinic receptor agonist, demonstrates neuroprotective effects against nigrostriatal damage in rats with unilateral 6-hydroxydopamine lesions. |
| In vivo | ABT-107 demonstrates strong bioavailability and CNS penetration across different species, including mice, rats, and monkeys, with variable oral and injection-based absorption rates (mice: orally 51.1%, intraperitoneally 100%; rats: orally 81.2%, intraperitoneally 100.0%; monkeys: orally 40.6%, intramuscularly 100%). It effectively increases ERK1/2 and CREB levels in a dose-dependent manner when administered intraperitoneally at doses ranging from 0.01 to 1 μmol/kg, 15 minutes before sacrifice. Additionally, at doses of 0.01, 0.1, and 1.0 mg/kg intraperitoneally, ABT-107 enhances S 9 -GSK3 activity and reduces p-tau in the mouse cortex and hippocampus. A daily intraperitoneal infusion of 5 mg/kg effectively mitigates tau hyperphosphorylation in AD transgenic APP-tau mice. In Sprague-Dawley male rats (350-380 g), daily intraperitoneal injections of 1 and 3 μmol/kg for three consecutive days significantly increase ACh release by day 3, suggesting a dose-dependent relationship and the necessity of higher doses for naive rats not exhibiting cognitive-related behavior. Furthermore, in female TAPP mice and their wild-type littermates, a continuous subcutaneous infusion of 1 mg/kg for two weeks elevates Ser9 phosphorylation in the cingulate cortex 15 minutes after acute administration, exhibiting the compound's pharmacodynamic effects in both induced and naturalistic animal models. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | ABT-107 | ABT107 | ABT 107 |
| Inhibitors Related | Adiphenine hydrochloride | Levamisole hydrochloride | Ethyl (triphenylphosphoranylidene) acetate | Urethane | Hexamethonium Bromide | Ribavirin | Adenine | Mitotane | Choline chloride | Propoxur | N,N-Dicyclohexylcarbodiimide | Arecoline |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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