Product Details
| Product Name:
ABT-963 |
CAS No.:
266320-83-6 |
| Purity:
98.58% |
Supply Ability:
10g |
| Release date:
2026/05/23 |
Product Introduction
Bioactivity
| Name | ABT-963 |
| Description | ABT-963 is a potent and selective inhibitor of disubstituted pyridazinone cyclooxygenase-2 (LOX2) that dose-dependently reduces injury perception in a carrageenan model of nociceptive sensitization.ABT-963 is used in the study of arthritis. |
| In vivo | Following oral administration, ABT-963 decreased prostaglandin E2 production in a rat carrageenan airbag model (ED50 of 0.4 mg/kg) and reduced edema in a carrageenan-induced paw edema model with an ED30 of 1.9 mg/kg.ABT-963 dose-dependently decreased injury perception in a carrageenan nociceptive hypersensitivity model (ED50 of 3.1 mg/kg ). After 14 days of administration in an adjuvant arthritis model, ABT-963 had an ED(50) of 1.0 mg/kg in reducing hind paw swelling.[1] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | LOX-2 | ABT-963 |
| Inhibitors Related | Naproxen sodium | Caffeic Acid | Acetaminophen | Phenidone | Gallic Acid Monohydrate | Diclofenac Potassium | Indomethacin | Paradol | Trometamol | 5-Methylfurfural | Phenylbutazone | Magnesium sulfate |
| Related Compound Libraries | Ferroptosis Compound Library | Bioactive Compound Library | Neuronal Signaling Compound Library | ReFRAME Related Library | Anti-Obesity Compound Library | Inhibitor Library | Metabolism Compound Library | Lipid Metabolism Compound Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | Fluorochemical Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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