Acarbose NEW
| Price | $79 |
| Package | 1g |
| Supply Ability: | 10g |
| Update Time: | 2026-05-11 |
Product Details
| Product Name: Acarbose | CAS No.: 56180-94-0 |
| Purity: 99.88% | Supply Ability: 10g |
| Release date: 2026/05/11 |
Product Introduction
Bioactivity
| Name | Acarbose |
| Description | Acarbose (BAY g 5421) is a hypoglycemic agent that is an inhibitor of orally active alpha-glucosidase (IC50=11 nM). Acarbose enhances the hypoglycemic effect of sulfonylureas or insulin. |
| Cell Research | Cell viability is determined using the MTT assay. Cells are seeded in 24-well culture plates at a density of 2×104 cells/well, incubated for 48 h, treated with acarbose at varying concentrations (0.5, 1.0, 2.0, 3.0, and 5.0 μM) for 24 h; or pre-treated with TNF-α (20 ng/mL) for either 24 h or 48 h to evaluate the dose-dependent effects of acarbose on VSMC growth and viability, cultured with 0.5 mg/mL MTT at 37°C in a humidified atmosphere of 5% CO2 for another 4 h, and solubilized with isopropanol. The viable cell number varies directly with the concentration of formazan product measured spectrophotometrically at 563 nm. |
| In vitro | METHODS: A7r5 cells pretreated with TNF-α were treated with Acarbose (1, 2, and 3 μM) and the expression levels of target proteins were detected by Western Blot. RESULTS: Acarbose decreased the expression of β-galactosidase and Ras and increased the expression of p-AMPK in a dose-dependent manner. [1] |
| In vivo | METHODS: To study the hypoglycemic effect of Acarbose, rats were treated with Acarbose (30, 60 mg/kg) by gavage once daily for 8 weeks. RESULTS: Acarbose reduced fasting glucose and modulated glucose tolerance without weight loss in DM rats. Acarbose significantly inhibited serum IL6 and TNF-α in DM rats. [2] METHODS: To study the effect of Acarbose on atherosclerosis, rabbits were fed Acarbose (2.5-5.0 mg/kg) for 25 weeks. RESULTS: Acarbose significantly and dose-dependent reduced the intensity of IL-6, TNF-α and iNOS staining, and significantly increased the intensity of p-AMPK staining in the neointima. Acarbose significantly and dose-dependent reduced neointimal Ras and β-galactosidase expression in HCD-fed rabbits without weight loss. [1] |
| Storage | Keep away from direct sunlight Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 50.00 mg/mL (77.45 mM), Sonication is recommended. H2O : 64.50 mg/mL (99.91 mM), Sonication is recommended. |
| Keywords | α-glucosidase | oral | mellitus | insulin | Inhibitor | inhibit | Glucosidase | BAY g-5421 | BAY g5421 | antihyperglycemic | anti-diabetes | Acarbose |
| Inhibitors Related | Cedryl acetate | X-GAL | Hexylresorcinol | Conduritol B epoxide | Gcase activator 2 | Fucoidan | Miglitol | Ambroxol hydrochloride | D-(-)-Quinic acid | (E)-3-(4-Methoxyphenyl)acrylic acid | Naringinase | 3-Butylidenephthalide |
| Related Compound Libraries | Anti-Tumor Natural Product Library | Bioactive Compound Library | Anti-Obesity Compound Library | Saccharide and Glycoside Natural Product Library | Drug Repurposing Compound Library | Inhibitor Library | Microbial Natural Product Library | FDA-Approved Drug Library | Metabolism Compound Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | Human Metabolite Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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