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Postion:Product Catalog >Biochemical Engineering>Biochemical Reagents>Agonist Inhibitors>Acolbifene
Acolbifene
  • Acolbifene

Acolbifene NEW

Price $76 $147
Package 1mg 5mg
Supply Ability: 10g
Update Time: 2025-08-22

Product Details

Product Name: Acolbifene CAS No.: 182167-02-8
Purity: 98.17% Supply Ability: 10g
Release date: 2025/08/22

Product Introduction

Bioactivity

NameAcolbifene
DescriptionAcolbifene (SCH 57068) is a selective antagonist of estrogen receptors with IC50s of 2 nM and 0.4 nM for estradiol-induced transcriptional activity of ERα and ERβ. Acolbifene shows an anticarcinogenic property.
In vitroAcolbifene supports the involvement of the clearance-related receptors in its hypocholesterolemic action without affecting pathways of cholesterol synthesis[2]. Acolbifene inhibits estradiol-stimulated cell proliferation in human breast cancer cancer cells including ZR-75-1, MCF-7 and T-47D[4].
In vivoIn female Sprague-Dawley rats, Acolbifene (2.5 mg/kg; gavage) reduces food intake, strongly decreases cholesterolemia and prevents tumor growth. Acolbifene reduces food intake (16%) and weight gain (45%, mainly fat)[2].
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility InformationDMSO : 40 mg/mL (87.4 mM), Sonication is recommended.
KeywordsSCH-57068 | SCH57068 | EstrogenReceptor | Estrogen Receptor | Erβ | Erα | ERR | EM652 | EM 652 | Acolbifene
Inhibitors RelatedKaempferol | Tamoxifen | Estradiol | Estradiol benzoate | ARV-471 | Octinoxate | Genistin | Estriol | Chrysin | Ethisterone | Cholesterol | Estrone

Company Profile Introduction

TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds. 170+ Compound Libraries, 10000+ Noval Small Molecucles,16000+ Nature Compounds TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.

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TargetMol Chemicals Inc.

2YR United StatesUnited States
  • Since: 2011-01-07
  • Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
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