Acotiamide NEW
| Price | $1520 | $1980 | $2500 |
| Package | 25mg | 50mg | 100mg |
| Supply Ability: | 10g |
| Update Time: | 2026-05-11 |
Product Details
| Product Name: Acotiamide | CAS No.: 185106-16-5 |
| Supply Ability: 10g | Release date: 2026/05/11 |
Product Introduction
Bioactivity
| Name | Acotiamide |
| Description | Acotiamide is an orally active, selective, and reversible acetylcholinesterase (AChE) inhibitor with an IC50 of 1.79 μM. It is a gastroprokinetic agent that enhances gastric contractility and accelerates delayed gastric emptying, with potential for research in functional dyspepsia involving gastric motility dysfunction and intestinal inflammatory [1] [2] [3]. |
| In vitro | Acotiamide (10, 30, 100 μM; 1 hour) significantly reduces IκB-α phosphorylation levels in LPS- and MCP-1-activated NR8383 macrophage cell lines, leading to a noticeable decrease in TNF-α and IL-6 production, as observed in Cell Viability Assays [1]. |
| In vivo | Acotiamide demonstrates a dose-dependent enhancement in postprandial gastric motility indices when administered either intravenously (0.3, 1, 3 mg/kg) or orally (3, 10, 30 mg/kg) [2]. A single intravenous dose (0.83 mg/kg) of acotiamide significantly inhibits acetylcholinesterase (AChE) activity in the rat stomach, with an IC 50 value of 1.79 μM, thereby potentially improving functional dyspepsia [3]. These findings were observed in experiments involving male mongrel dogs weighing 9-11 kg and male beagle dogs weighing 9.6-12.9 kg for the gastric motility study [2], and male Sprague-Dawley rats aged 6-7 weeks for the AChE inhibition study [3]. The results indicate acotiamide's effectiveness in increasing postprandial gastric motility and inhibiting AChE in the stomach, evidenced by detailed animal models and specific dosage administrations. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | Acotiamide |
| Inhibitors Related | Uridine 5'-monophosphate disodium salt | Ethyl (triphenylphosphoranylidene) acetate | Methylene Violet 3RAX | 4-Methylbenzylidene camphor | (±)-Dihydroactinidiolide | Diethyltoluamide | Pralidoxime Iodide | Propoxur | Dimethyl sulfoxide | Coumaran | Methyl tridecanoate | Trimethylammonium chloride |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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