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Postion:Product Catalog >ACY-1083
ACY-1083
  • ACY-1083

ACY-1083 NEW

Price $155 $328 $559
Package 1mg 5mg 10mg
Supply Ability: 10g
Update Time: 2026-05-16

Product Details

Product Name: ACY-1083 CAS No.: 1708113-43-2
Purity: 99.19% Supply Ability: 10g
Release date: 2026/05/16

Product Introduction

Bioactivity

NameACY-1083
DescriptionACY-1083 is a small molecule inhibitor, a highly selective HDAC6 inhibitor (IC50=3 nM), with 260-fold higher selectivity over other classes of HDAC isoforms. It is brain-penetrant and used for research on chemotherapy-induced peripheral neuropathy.
In vitroMethods: Air-liquid interface cultures of bronchial epithelial cells derived from COPD patients were treated with 10 μM ACY-1083, and stimulated with TNF, TGF-β, cigarette smoke, or bacteria. Epithelial barrier function (TEER, FITC-dextran permeability), inflammatory factors (MSD, qPCR), morphology (AB/PAS staining), and ciliary function were detected. Results: ACY-1083 significantly reduced stimulus-induced permeability increase, decreased release of inflammatory factors such as IL-6 and CCL2, protected epithelial morphology and ciliary function, and maintained mucus clearance.[1]
In vivoMethods: In adult male SD rat models, ACY-1083 (3 mg/kg) was administered orally to detect its reversal effect on paclitaxel-induced mechanical allodynia; in C57BL/6J mice, ACY-1083 (5 mg/kg) was administered via intraperitoneal injection for pharmacokinetic analysis, detecting blood drug concentration, half-life, and biologically effective plasma exposure time. Results: ACY-1083 reversed paclitaxel-induced mechanical allodynia. ACY-1083 exhibited a maximum blood concentration (Cmax) of 936 ng/mL, a half-life (T1/2) of 3.5 hours, and 8 hours of biologically effective plasma exposure time. [1] Methods: In C57BL/6J mouse models, ACY-1083 (10 mg/kg) was administered via intraperitoneal injection to detect its alleviating effect on cisplatin-induced mechanical allodynia. Results: ACY-1083 effectively alleviated cisplatin-induced mechanical allodynia. [2]
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
Solubility Information10% DMSO+40% PEG300+5% Tween 80+45% Saline : 5 mg/mL (14.35 mM), Sonication is recommended.
DMSO : 237.5 mg/mL (681.79 mM), Sonication is recommended.
KeywordsHDAC6 | ACY-1083 | ACY1083 | ACY 1083
Inhibitors RelatedPanobinostat | Theophylline monohydrate | Valproic acid sodium salt | Methoxyacetic acid | Sodium 4-phenylbutyrate | Acefylline | Manganese chloride (tetrahydrate) | Curcumin | Valproic Acid | Sodium butanoate | 4-Phenylbutyric acid | Theophylline
Related Compound LibrariesReprogramming Compound Library | Histone Modification Compound Library | DNA Damage & Repair Compound Library | Bioactive Compound Library | Epigenetics Compound Library | Chromatin Modification Compound Library | Hematonosis Compound Library | Inhibitor Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Fluorochemical Library | Anti-Cancer Compound Library

Company Profile Introduction

TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds. 170+ Compound Libraries, 10000+ Noval Small Molecucles,16000+ Nature Compounds TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.

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TargetMol Chemicals Inc.

2YR United StatesUnited States
  • Since: 2011-01-07
  • Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
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