ADDA 5 hydrochloride NEW
| Price | $35 |
| Package | 2mg |
| Supply Ability: | 10g |
| Update Time: | 2026-04-22 |
Product Details
| Product Name: ADDA 5 hydrochloride | CAS No.: 473268-46-1 |
| Purity: 99.84% | Supply Ability: 10g |
| Release date: 2026/04/22 |
Product Introduction
Bioactivity
| Name | ADDA 5 hydrochloride |
| Description | ADDA 5 hydrochloride is a specific and non-competitive inhibitor of CcO (cytochrome c oxidase) that inhibits the proliferation of chemically sensitive and chemically resistant glioma cells and blocks cell proliferation and neurosphere formation in glioma stem cell cultures. |
| In vitro | Method: ADDA 5 hydrochloride was used to treat cytochrome c oxidase (CcO) purified from human glioma cells and bovine heart, as well as glioblastoma stem cell (GSC) lines derived from UTMZ and Jx22, to evaluate its inhibitory effects on CcO activity and cell proliferation. Result: ADDA 5 hydrochloride partially and non-competitively inhibited CcO from human glioma and bovine heart, with IC?? values of 18.93 μM and 31.82 μM, respectively. It also inhibited CcO activity in UTMZ and Jx22 GSCs, with IC?? values of 21.4 μM and 15.5 μM, and exhibited antiproliferative effects on UTMZ cells (EC?? = 8.17 μM).[1] |
| In vivo | Method: ADDA 5 was administered intraperitoneally (i.p.) at a dose of 8 mg/kg to tumor-bearing mice to evaluate its antitumor efficacy and in vivo toxicity. Result: ADDA 5 (8 mg/kg, i.p.) significantly inhibited tumor growth in mice, and no detectable toxicity was observed at doses up to 80 mg/kg. [1] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (4.93 mM), Sonication is recommended. DMSO : 50 mg/mL (123.15 mM), Sonication is recommended. H2O : 1 mg/mL (2.46 mM), Sonication is recommended. |
| Keywords | CcO, human glioma | CcO, bovine heart | ADDA-5 Hydrochloride | ADDA 5 Hydrochloride |
| Inhibitors Related | Tebuconazole | Oxadiazon | Musk ketone | Naringin dihydrochalcone | Ipriflavone | Benzyl alcohol | Sudan IV | Naringin | Tauroursodeoxycholate | Dibenzothiophene | Clarithromycin | Memantine hydrochloride |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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