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Postion:Product Catalog >Biochemical Engineering>Polypeptide>Adipotide
Adipotide
  • Adipotide

Adipotide

Price Get Latest Price
Package 1box 10box 100box
Min. Order: 1box
Supply Ability: 20tons
Update Time: 2026-06-08

Product Details

Product Name: Adipotide Min. Order: 1box
Purity: 99% Supply Ability: 20tons
Release date: 2026/06/08

Adipotide Product Introduction

Overview Mechanism of Action

Targeted vascular homing: The sequence CKGGRAKDC (with a disulfide?closed ring) preferentially binds prohibitin on the endothelium of white adipose tissue vessels, providing adipose?selective accumulation.

Receptor?mediated internalization: Binding triggers endocytosis and trafficking to mitochondria.

Mitochondrial disruption: The effector (KLAKLAK)? adopts an amphipathic helix, inserts into the mitochondrial membrane, and induces cytochrome c release and caspase?dependent apoptosis.

Vascular collapse and fat loss: Apoptotic endothelial cells are cleared, adipose perfusion falls, and adipocytes undergo stress/apoptosis, leading to a net reduction in fat mass6.

Key Research Findings

In a study of obese rhesus monkeys, daily subcutaneous administration for 4 weeks led to an average 11% reduction in body weight and ~39% reduction in fat mass, alongside improved insulin sensitivity (insulin use ~60% lower than baseline). These data were published in Science Translational Medicine (2011) and highlighted a primate?relevant pathway for selective fat reduction distinct from appetite or fat?absorption modulationResearch Applications and Safety

Applications:

Vascular targeting and anti?angiogenic mechanism studies

White adipose tissue biology and body composition research

Metabolic consequence analysis (e.g., insulin sensitivity) in preclinical obesity models

Safety and handling:

For laboratory research only; not for human or animal consumption

Observe institutional biosafety and ethical guidelines; use appropriate PPE and aseptic techniques

Note on adverse effects: Preclinical primate studies reported dehydration and kidney lesions at certain doses; these findings underscore the importance of dose?response evaluation and are not indicative of humanty or efficacy

Article illustration

Company Profile Introduction

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