Adrenalone hydrochloride NEW
| Price | $30 | $43 | $98 |
| Package | 50mg | 100mg | 500mg |
| Supply Ability: | 10g |
| Update Time: | 2026-04-20 |
Product Details
| Product Name: Adrenalone hydrochloride | CAS No.: 62-13-5 |
| Purity: 99.94% | Supply Ability: 10g |
| Release date: 2026/04/20 |
Product Introduction
Bioactivity
| Name | Adrenalone hydrochloride |
| Description | Adrenalone hydrochloride (Adrenalone HCl) is a dopamine β-oxidase inhibitor with a similar structure to the norepinephrine transporter (NET) ligand, with an IC50 of 36.9 μM. It is an adrenergic agonist that acts as a local vasoconstrictor and hemostatic agent. |
| In vitro | Adrenalone is the ketone form of adrenaline, which is used as a topical hemostatic agent, vasoconstrictor, and nasal vasoconstrictor. In a nitrogenated aqueous solution containing 10 or 100 mM tert-butanol, Adrenalone (0.1 mM) reduces Adrenalone by hydration of electrons, resulting in the same transient spectrum, and thus all OH radicals are scavenged. Although Adrenalone acted similarly to carbonyl compounds in the reduction process, it was mainly controlled by catechol functional groups in the oxidation reaction. Adrenalone (12 μM) inhibited the conversion of dopamine to norepinephrine by inhibiting dopamine β-oxidase. Unlike Epinine, which has a keto group in the β-site, Adrenalone contains an amine group (ionic bond with Asp75), an aromatic ring (hydrophobic interactions with Tyr152, Phe72, and Phe317), and a hydroxyl group (hydrogen bonding with Ala145).10 μM and 100 μM Adrenalone 10 μM and 100 μM Adrenalone reduced substrate uptake by 99% and 27%, respectively. |
| In vivo | Adrenalone is the ketone form of adrenaline, which is used as a topical hemostatic agent, vasoconstrictor, and nasal vasoconstrictor. In a nitrogenated aqueous solution containing 10 or 100 mM tert-butanol, Adrenalone (0.1 mM) reduces Adrenalone by hydration of electrons, resulting in the same transient spectrum, and thus all OH radicals are scavenged. Although Adrenalone acted similarly to carbonyl compounds in the reduction process, it was mainly controlled by catechol functional groups in the oxidation reaction. Adrenalone (12 μM) inhibited the conversion of dopamine to norepinephrine by inhibiting dopamine β-oxidase. Unlike Epinine, which has a keto group in the β-site, Adrenalone contains an amine group (ionic bond with Asp75), an aromatic ring (hydrophobic interactions with Tyr152, Phe72, and Phe317), and a hydroxyl group (hydrogen bonding with Ala145).10 μM and 100 μM Adrenalone 10 μM and 100 μM Adrenalone reduced substrate uptake by 99% and 27%, respectively. |
| Storage | Powder: -20°C for 3 years Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (9.19 mM), Sonication is recommended. Ethanol : < 1 mg/mL (insoluble or slightly soluble) DMSO : 60 mg/mL (275.67 mM), Sonication is recommended. H2O : 40 mg/mL (183.78 mM), Sonication is recommended. |
| Keywords | α1-adrenergic receptor | Tyrosine | Syk | Src | signaling | Pyroptosis | Potassium | Piceatannol | PAR | kinase | Inhibitor | inhibit | Inflammation | Inflammasome | GPVI | Beta Receptor | AdrenergicReceptor | Adrenergic Receptor | Adrenalone hydrochloride | Adrenalone |
| Inhibitors Related | Trifluoperazine dihydrochloride | Mirtazapine | Octopamine hydrochloride | Gemfibrozil | Buflomedil hydrochloride | Dexmedetomidine hydrochloride | Isoprenaline hydrochloride | D-Mannitol | Mianserin hydrochloride | Trazodone hydrochloride | Atenolol | Doxepin hydrochloride |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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