AG-024322 NEW
| Price | $699 |
| Package | 2mg |
| Supply Ability: | 10g |
| Update Time: | 2026-05-11 |
Product Details
| Product Name: AG-024322 | CAS No.: 837364-57-5 |
| Purity: 98.53% | Supply Ability: 10g |
| Release date: 2026/05/11 |
Product Introduction
Bioactivity
| Name | AG-024322 |
| Description | AG-024322 is a potent ATP-competitive inhibitor targeting pan-CDK, effectively inhibiting cell cycle kinases CDK1, CDK2, and CDK4 with Ki values in the 1-3 nM range (1-3 nM). |
| In vitro | Biotin-PEG4-Picolyl azide can utilize the ubiquitin-proteasome system to achieve selective elimination of target proteins through E3 ubiquitin ligase-mediated specific degradation of target proteins [1]. |
| In vivo | In male and female cynomolgus monkeys, AG-024322 (at doses of 2, 6, and 10 mg/kg; intravenous infusion; over 5 days) resulted in dose-dependent pancytopenic bone marrow hypocellularity and lymphoid depletion in lymph nodes, spleen, and/or thymus at doses greater than 6 mg/kg[1]. |
| Storage | Store at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 3.3 mg/mL (7.89 mM), Sonication is recommended. DMSO : 80 mg/mL (191.19 mM), Sonication is recommended. |
| Keywords | CDK4 | CDK2 | CDK1 | CDK |
| Inhibitors Related | Stavudine | Aceglutamide | Urea | Tamoxifen | Cysteamine hydrochloride | Metronidazole | Citric Acid Triammonium | Formamide | Trometamol | Dimethyl phthalate | Alginic acid | Sildenafil citrate |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, MA
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