Agomelatine hydrochloride NEW
| Price | $36 | $64 | $107 |
| Package | 10mg | 25mg | 50mg |
| Supply Ability: | 10g |
| Update Time: | 2026-06-02 |
Product Details
| Product Name: Agomelatine hydrochloride | CAS No.: 1176316-99-6 |
| Purity: 99.57% | Supply Ability: 10g |
| Release date: 2026/06/02 |
Product Introduction
Bioactivity
| Name | Agomelatine hydrochloride |
| Description | Agomelatine hydrochloride (S-20098 hydrochloride) is a specific MT1 and MT2 receptor agonist with Ki values of 0.1 nM for CHO-hMT1, 0.06 nM for HEK-hMT1, 0.12 nM for CHO-hMT2, and 0.27 nM for HEK-hMT2, respectively [1]. Additionally, Agomelatine hydrochloride is a selective antagonist of the 5-HT2C receptor with pKi values of 6.4 and 6.2 for native (porcine) and cloned human 5-HT2C receptors, respectively [2]. |
| In vitro | Agomelatine (S 20098) functions as a full agonist for the MT1 and MT2 receptors, exhibiting EC50 values of 1.6±0.4 and 0.10±0.04 nM, respectively, when expressed in CHO or HEK cell membranes. Additionally, Agomelatine interacts with h5-HT2B receptors, displaying a marked preference (6.6). However, it demonstrates low affinity for both native and cloned human 5-HT2A receptors, with values just below 5.0/5.3, and similarly low affinity for 5-HT1A receptors (below 5.0/5.2), while exhibiting negligible affinity for other 5-HT receptors. |
| In vivo | Agomelatine (25, 50, or 75 mg/kg; i.p.) exhibits antioxidant activity in Strychnine (75 mg/kg, i.p.) or Pilocarpine (400 mg/kg, i.p.) induced seizure models in mice, but does not affect oxidative stress parameters in Pentylenetetrazole (PTZ) or Picrotoxin (PTX) induced seizure models compared to controls[3]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+90% Saline : 10 mg/mL (35.74 mM), Suspension. H2O : 0.1 mg/mL (0.36 mM) 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 3.3 mg/mL (11.8 mM), Sonication is recommended. DMSO : 125 mg/mL (446.81 mM), Sonication is recommended. |
| Keywords | S-20098 Hydrochloride | S20098 Hydrochloride | S 20098 Hydrochloride | MTReceptor | MT2 receptor | MT1 receptor | MT Receptor | Agomelatine Hydrochloride |
| Inhibitors Related | Sucrose | Aceglutamide | Nicotinamide riboside malate | D(+)-Raffinose pentahydrate | Guanidine hydrochloride | Malic acid | Formamide | Glycerol | Thymidine | Corn starch | Gluconate Calcium | DL-Lysine |
| Related Compound Libraries | FDA-Approved & Pharmacopeia Drug Library | Failed Clinical Trials Compound Library | Bioactive Compound Library | Anti-Neurodegenerative Disease Compound Library | Antidepressant Compound Library | EMA Approved Drug Library | Drug Repurposing Compound Library | Inhibitor Library | Bioactive Compounds Library Max | GPCR Compound Library | NMPA-Approved Drug Library | Serotonin Receptor-Targeted Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, MA
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