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Postion:Product Catalog >AMD 3465 hexahydrobromide
AMD 3465 hexahydrobromide
  • AMD 3465 hexahydrobromide

AMD 3465 hexahydrobromide NEW

Price $31 $43 $85
Package 5mg 10mg 25mg
Supply Ability: 10g
Update Time: 2026-06-02

Product Details

Product Name: AMD 3465 hexahydrobromide CAS No.: 185991-07-5
Purity: 99.39% Supply Ability: 10g
Release date: 2026/06/02

Product Introduction

Bioactivity

NameAMD 3465 hexahydrobromide
DescriptionAMD 3465 hexahydrobromide (GENZ-644494 (hexahydrobromide)) is a CXCR4 receptor antagonist with potential anticancer and anti-HIV activity.
In vitroAMD 3465 hexahydrobromide inhibits binding of 12G5 mAb and CXCL12AF647 to CXCR4, with IC50s of 0.75 nM and 18 nM in SupT1 cells.?AMD 3465 (50 nM) totally blocks CXCL12-induced calcium mobilization, with an IC50 of 17 nM, but shows no effect on the intracellular calcium fluxes elicited by the CCR5 ligands RANTES, LD78β and MIP-1β in U87.CD4.CCR5 cells.?AMD 3465 also potently inhibits the replication of X4 HIV strains (IC50: 1-10 nM), but has no effect on CCR5-using (R5) viruses.?AMD3465 is cytotoxic to the X4 HIV-1 strains IIIB, NL4.3, RF and HE with an IC50 ranging from 6 to 12 nM.?The IC50 for suppression of the HIV-2 strains ROD and EHO is 12.3 nM[1].?AMD 3465 inhibits CXCL-12-induced growth in U87 and Daoy cells.?AMD 3465 treatment stimulates the phosphorylation of Erk1/2 in U87 and Daoy cells[2].
In vivoAdministering 2.5 mg/kg/d of AMD 3465 subcutaneously for five weeks significantly inhibits the growth of U87 glioblastoma multiforme (GBM) and Daoy medulloblastoma xenografts.
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
Solubility Information10% DMSO+40% PEG300+5% Tween 80+45% Saline : 10 mg/mL (11.16 mM), Solution.
H2O : 38 mg/mL (42.41 mM), Sonication is recommended.
10% DMSO+90% Saline : < 10 mg/mL (11.16 mM), Lower concentrations may be soluble, but exact solubility limit is unknown.
DMSO : 250 mg/mL (279 mM), Sonication is recommended.
KeywordsX4 HIV-1 (RF) | X4 HIV-1 (NL4.3AMD3100) | X4 HIV-1 (NL4.3) | X4 HIV-1 (IIIB) | X4 HIV-1 (HE) | Inhibitor | inhibit | Human immunodeficiency virus | HIVProtease | HIV-2 (ROD) | HIV-2 (EHO) | HIV Protease | HIV | GENZ-644494 hexahydrobromide | GENZ-644494 | GENZ644494 | GENZ 644494 | CXCR4 | CXCR | CXCL12AF647-CXCR4 | CXC chemokine receptors | AMD-3465 Hexahydrobromide | AMD3465 Hexahydrobromide | AMD-3465 | AMD3465 | AMD 3465 hexahydrobromide | AMD 3465 | 12G5 mAb-CXCR4
Inhibitors RelatedStavudine | 5-Fluorouracil | Emtricitabine | Dolutegravir intermediate-1 | Dimethyl fumarate | Lamivudine | Chloroquine phosphate | Valproic Acid | (-)-Epigallocatechin Gallate | Decanedioic acid | Dextran sulfate sodium salt (MW 5000) | Tenofovir
Related Compound LibrariesTarget-Focused Phenotypic Screening Library | Bioactive Compound Library | Membrane Protein-targeted Compound Library | Hematonosis Compound Library | Autophagy Compound Library | Anti-Viral Compound Library | Inhibitor Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | GPCR Compound Library | Anti-Infection Compound Library | Anti-Cancer Active Compound Library

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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TargetMol Chemicals Inc.

6YR United StatesUnited States
  • Since: 2011-01-07
  • Address: 36 Washington Street, Wellesley Hill, MA
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