AP-III-a4 NEW
| Price | $47 | $123 | $198 |
| Package | 1mg | 5mg | 10mg |
| Supply Ability: | 10g |
| Update Time: | 2026-07-15 |
Product Details
| Product Name: AP-III-a4 | CAS No.: 1177827-73-4 |
| Purity: 98.24% | Supply Ability: 10g |
| Release date: 2026/07/15 |
Product Introduction
Bioactivity
| Name | AP-III-a4 |
| Description | AP-III-a4 (ENOblock) is the first non-substrate analogue that directly binds to enolase to inhibit its catalytic activity with an IC50 of 0.576 μM, thereby blocking cancer cell metastasis in vivo. AP-III-a4 can be used in research on tumor metabolism, metastasis, and diseases related to carbohydrate metabolism. |
| Cell Research | HCT116 cells(3 x 10E5) are seeded in a 6 well plate. 24 h later, cells are treated with AP-III-a4 (5 μM) for 24hours. |
| Kinase Assay | Enolase activity assay is in the 2.0 mM MgSO4 and 400 mM KCl in the absence or presence of ENOblock or NaF, at 37°C by incubating pure enolase (3–9 U) in a buffer containing 50 mM imidazole-HCl (pH 6.8). The reaction is initiated by adding 1 μmol of 2-phospho-D-glycerate, and the OD is measured after 10 min of reaction time with a spectrophometer at 240 nm. |
| Animal Research | In HCT116-xenotransplanted zebrafish tumor xenograft model, were treated with AP-III-a4 of 10 μM. |
| In vitro | Methods: H446 cells were treated with AP-III-a4 (1 μM) for 24 hours, followed by detection of ENO1 enzyme activity using the ENO1 Human Activity Assay Kit. Results: AP-III-a4 treatment inhibited ENO1 activity. [1] |
| In vivo | Methods: UM-1 cells (1×10?) were subcutaneously implanted into nude mice. Once tumor volume reached 100 mm3, AP-III-a4 was administered via intraperitoneal injection at a dose of 20 mg/kg body weight, every other day for 28 days. Results: Tumor volume and weight in AP-III-a4-treated mice were significantly smaller than in the control group. [2] |
| Storage | Store at low temperature,Keep away from direct sunlight, Pure form: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 257.5 mg/mL (432.98 mM), Sonication is recommended. H2O : < 1 mg/mL (insoluble or slightly soluble) 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 5 mg/mL (8.41 mM), Sonication is recommended. |
| Keywords | zebrafish | Phosphopyruvate hydratase | Inhibitor | inhibit | Huh7 | HEK | HCT116 | enolase | Apoptosis | AP-III-a-4 | AP-III-a4 | APIIIa4 | AP III a4 | antidiabetic | anticancer |
| Inhibitors Related | Stavudine | Aceglutamide | Urea | Tamoxifen | Cysteamine hydrochloride | Metronidazole | Citric Acid Triammonium | Formamide | Dimethyl phthalate | Alginic acid | Sodium Molybdate | Sildenafil citrate |
| Related Compound Libraries | Glycolysis Compound Library | Glycometabolism Compound Library | Bioactive Compound Library | Kinase Inhibitor Library | Anti-Cancer Metabolism Compound Library | Post-Translational Modification Compound Library | Inhibitor Library | NO PAINS Compound Library | Metabolism Compound Library | Bioactive Compounds Library Max | Fluorochemical Library | Anti-Cancer Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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