Product Details
| Product Name:
Apafant |
CAS No.:
105219-56-5 |
| Purity:
99.56% |
Supply Ability:
10g |
| Release date:
2026/05/11 |
Product Introduction
Bioactivity
| Name | Apafant |
| Description | Apafant (WEB 2086) is a highly potent platelet activating factor (PAF) antagonist that blocks eosinophil activation and can be used to study experimental allergic conjunctivitis in guinea pigs. |
| In vivo | Guinea pigs were actively sensitized and OA solution was instilled into the eyes of guinea pigs on Days 15 and 17 to elicit the allergic conjunctivitis. To examine the effects of Apafant on allergic conjunctivitis, Apafant ophthalmic solution was topically administered 0.1%, 1%, q.i.d. through Days 14 to 17. Compared to the controls (vehicle treatments), the animals treated with Apafant ophthalmic solution showed significantly reduced clinical symptoms (redness and edema) and itch-scratch responses in both the first and second antigen challenges. [1] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween-80+45% Saline : 3.3 mg/mL (7.24 mM), Sonication is recommended.
DMSO : 30 mg/mL (65.8 mM), Sonication is recommended.
|
| Keywords | Platelet-activating factor | PAFR | Apafant |
| Inhibitors Related | Cedrol | Ginkgolide B | PAF C-18 | (Rac)-Modipafant | CP 96021 | Rupatadine | 48740 RP | SDZ-62-434 | Rocepafant | Rupatadine Fumarate | 2-Acetylbenzoic acid | Dersalazine |
| Related Compound Libraries | Bioactive Compound Library | Membrane Protein-targeted Compound Library | ReFRAME Related Library | Drug Repurposing Compound Library | Immunology/Inflammation Compound Library | Clinical Compound Library | Bioactive Compounds Library Max | GPCR Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
Recommended supplier
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$56.00
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TargetMol Chemicals Inc.
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