Apcin NEW
| Price | $40 | $57 | $89 |
| Package | 1mg | 2mg | 5mg |
| Supply Ability: | 10g |
| Update Time: | 2026-06-02 |
Product Details
| Product Name: Apcin | CAS No.: 300815-04-7 |
| Purity: 96.74% | Supply Ability: 10g |
| Release date: 2026/06/02 |
Product Introduction
Bioactivity
| Name | Apcin |
| Description | Apcin is a potent and competitive inhibitor of anaphase-promoting complex/cyclosome (APC/C(Cdc20)) E3 ligase activity. Apcin competitively inhibits APC/C-dependent ubiquitylation by binding to Cdc20 and preventing substrate recognition. It acts by blocking mitotic exit and being synergistically amplified by co-addition of Ts-Arg-OMe. |
| In vitro | apcin as a small molecule ligand of Cdc20 that inhibits APC/CCdc20 and prolongs mitosis.?apcin paradoxically shortens mitosis when SAC activity is high.?These opposing effects of apcin arise from targeting of a common binding site in Cdc20 required for both substrate ubiquitination and MCC-dependent APC/C inhibition.?Furthermore, apcin cooperates with p31comet to relieve MCC-dependent inhibition of APC/C.?Apcin therefore causes either net APC/C inhibition, prolonging mitosis when SAC activity is low, or net APC/C activation, shortening mitosis when SAC activity is high, demonstrating that a small molecule can produce opposing biological effects depending on regulatory context. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 235 mg/mL (535.73 mM), Sonication is recommended. 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 10 mg/mL (22.8 mM), Solution. 10% DMSO+90% Saline : < 10 mg/mL (22.8 mM), Lower concentrations may be soluble, but exact solubility limit is unknown. |
| Keywords | WD40-domain | ubiquitylation | recognition | pocket | mitosis | ligase | Inhibitor | inhibit | cyclosome | complex | Cdc20 | Apcin | APC/C | APC | anaphase-promoting | Anaphase promoting complex |
| Inhibitors Related | TAME hydrochloride | TASIN-1 | TASIN-1 Hydrochloride | TAME | Bovine Protein C | Apcin A HCL | ProTAME | CFM 4 | Activated Protein C (390-404), human acetate | CP5V | Activated Protein C (390-404), human TFA | CDC20-IN-2 |
| Related Compound Libraries | Bioactive Compound Library | Inhibitor Library | NO PAINS Compound Library | Bioactive Compounds Library Max | Cell Cycle Compound Library | Anti-Cancer Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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VIP4Y
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TargetMol Chemicals Inc.
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2026-04-22 |
United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, MA
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