API-2
| Price | $1 |
| Package | 1g |
| Min. Order: | 1g |
| Supply Ability: | 100kg |
| Update Time: | 2024-10-23 |
Product Details
| Product Name: API-2 | CAS No.: 35943-35-2 |
| Min. Order: 1g | Purity: 99% |
| Supply Ability: 100kg | Release date: 2024/10/23 |
| API-2 Basic information |
| Product Name: | API-2 |
| Synonyms: | API-2;6-AMINO-4-METHYL-8-(BETA-D-RIBOFURANOSYL)-4H,8H-PYRROLO[4,3,2-DE]PYRIMIDO[4,5-C]PYRIDAZINE;AKT/PKB SIGNALING INHIBITOR-2;AKT INHIBITOR V;1,5-DIHYDRO-5-METHYL-1-BETA-D-RIBOFURANOSYL-1,4,5,6,8-PENTAAZAACENAPHTHYLEN-3-AMINE;1,4,5,6,8-pentaazaacenaphthylen-3-amine,1,5-dihydro-5-methyl-1-beta-d-ribofura;1,4,5,6,8-pentaazaacenaphthylene,3-amino-1,5-dihydro-5-methyl-1-beta-d-ribof;3-amine |
| CAS: | 35943-35-2 |
| MF: | C13H16N6O4 |
| MW: | 320.3 |
| EINECS: | |
| Product Categories: | Protein Kinase;Inhibitors;Akt;mTOR;PI3K |
| Mol File: | 35943-35-2.mol |
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| API-2 Chemical Properties |
| Boiling point | 459.21°C (rough estimate) |
| density | 1.2633 (rough estimate) |
| refractive index | 1.7000 (estimate) |
| storage temp. | Store at RT |
| solubility | DMSO: >10mg/mL |
| color | tan |
| InChIKey | HOGVTUZUJGHKPL-HTVVRFAVSA-N |
| Safety Information |
| RTECS | RY8455000 |
| MSDS Information |
| API-2 Usage And Synthesis |
| Chemical Properties | Off-White Solid |
| Uses | Triciribine is an antitumor tricyclic nucleoside. Triciribine acts as a potent, small-molecule inhibitor of AKT phosphorylation in subjects with solid tumors contining activated AKT. Triciribine is al so a selective inhibitor of HIV-1 and HIV-2, including strains known to be resistant to AZT or TIBO. |
| Biological Activity | Selective inhibitor of Akt (protein kinase B) signaling; displays minimal inhibition of PKC, PKA, SGK and p38 pathways. Inhibits phosphorylation and activation of downstream targets of Akt including Bad, GSK-3 β and AFX. In vitro, induces apoptosis and growth arrest preferentially in human cancer cells with elevated levels of Akt. In mice, potently and selectively inhibits growth of Akt-overexpressing tumors. Inhibits DNA synthesis and displays antiviral activity against HIV-1 and -2. |
Triciribine
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