Aprotinin NEW
| Price | $39 | $54 | $117 |
| Package | 5mg | 10mg | 25mg |
| Supply Ability: | 10g |
| Update Time: | 2026-05-11 |
Product Details
| Product Name: Aprotinin | CAS No.: 9087-70-1 |
| Supply Ability: 10g | Release date: 2026/05/11 |
Product Introduction
Bioactivity
| Name | Aprotinin |
| Description | Aprotinin (Traskolan) is a broad-spectrum serine protease (BPTI) inhibitor that inhibits the activity of a number of different esterases and proteases. Aprotinin is an antifibrinolytic agent used to minimize hemorrhage during complex surgical procedures. |
| Cell Research | Mouse G8-1 myoblasts are plated DMEM + 20% FBS (maintenance medium), in which they remain undifferentiated. When cells reach approximately 40-50% confluence, different protease inhibitors are added to the culture media and cells are incubated overnight. Cells are then switched to differentiation-promoting media (DMEM + 10% horse serum ± protease inhibitor) and incubated for 7 days. (Only for Reference) |
| Kinase Assay | Substrates and kinases are diluted in 50?mM Tris/HCl (pH?7.5), 0.1% 2-mercaptoethanol, 0.1?mM EGTA and 10?mM magnesium acetate. Reactions are initiated with [γ-32P]ATP (2500 c.p.m./pmol) to a final concentration of 0.1?mM and terminated after 15?min at 30°C by the addition of SDS and EDTA (pH?7.0) to final concentrations of 1.0% (w/v) and 20?mM respectively. After heating for 5?min at 100°C and separation by SDS/PAGE, the phosphorylated proteins are detected by autoradiography. |
| In vitro | METHODS: SARS-CoV-2 infected Caco2 cells were treated with Aprotinin (0-20 μM) for 48 h and cytopathic effect (CPE) was detected. RESULTS: Aprotinin showed antiviral effects on CPE formation in SARS-CoV-2 infected Caco2 cells with an IC50 range of 0.81 μM-1.03 μM. [1] METHODS: VSMCs cells were pretreated with Aprotinin (1-100 μM) for 1 h, treated with cytokines (10 ng/mL IL-1β+25 ng/ml TNF-α) for 12 h, and then the target gene and protein expression levels were detected by Western Blot and RT-PCR. RESULTS: Aprotinin stimulated a significant increase in HO-1 protein levels and mRNA levels with cytokines in a concentration-dependent manner. [2] |
| In vivo | METHODS: To study in vivo anti-influenza virus activity, Aprotinin (2 mg/kg) was administered intravenously twice daily for 5 days to lethally A/PR/8/34 (H1N1) virus-infected C57BL/6 mice. RESULTS: Aprotinin alone did not cause weight loss in mice, and the survival rate of PBS-treated mice was 0% at 8 days post-infection. Meanwhile, the group of mice treated with Aprotinin showed a 75% survival rate. [3] |
| Storage | Keep away from moisture Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | H2O : 242.5 mg/mL (37.24 mM), Sonication is recommended. |
| Keywords | trypsinogen | Trypsin | Threonine proteases | SerineProtease | Serine proteases | Serine Protease | Serine endopeptidases | Ser/Thr Protease | kallikrein | Inhibitor | inhibit | InfluenzaVirus | Influenza Virus | Chymotrypsin-like proteasome | Aprotinin |
| Inhibitors Related | Acetylcysteine | Nitazoxanide | Imidazole | Curcumin | 10-Undecenoic acid | Proteinase K | Baicalein | Ac-Ala-OH | Salcomine | Benzimidazole | 4'-Hydroxychalcone | β-Cyclodextrin |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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