ar-Turmerone NEW
| Price | $88 | $213 | $372 |
| Package | 1mg | 5mg | 10mg |
| Supply Ability: | 10g |
| Update Time: | 2026-04-28 |
Product Details
| Product Name: ar-Turmerone | CAS No.: 532-65-0 |
| Purity: 99.82% | Supply Ability: 10g |
| Release date: 2026/04/28 |
Product Introduction
Bioactivity
| Name | ar-Turmerone |
| Description | ar-Turmerone is a natural volatile organic compound extracted from the rhizomes of turmeric (Curcuma longa). ar-Turmerone exhibits oral bioavailability and possesses biological activities such as antitumor, anti-inflammatory, antioxidant, and neuroprotective effects. ar-Turmerone exerts a positive regulatory effect on dendritic cells in mice. Ar-turmerone can induce neural stem cell proliferation both in vitro and in vivo, making it useful for research on neurological disorders. Ar-turmerone induces apoptosis in U937 cells. |
| In vitro | Methods: ar-Turmerone (0, 50, 100, 200 μM) was added to U251, U87, and LN229 glioma cells, which were incubated for 48 hours; cell viability was assessed using the CCK-8 assay. Results: ar-Turmerone inhibited cell viability in a dose-dependent manner. [1] Methods: Primary rat hippocampal neurons were treated with ar-Turmerone (30, 100, 300 μM) for 1 hour, followed by treatment with Aβ25-35 (50 μM) for 24 hours. Cell viability was assessed using the MTT assay, and TNF-α, IFN-β, and iNOS levels were measured by ELISA. Results: ar-Turmerone restored cell viability in a dose-dependent manner and reduced TNF-α, IFN-β, and iNOS levels in a dose-dependent manner. [2] Methods: Primary fetal mouse (E14.5) cortical neural stem cells (containing FGF2) were treated with ar-Turmerone (1.56–25 μg/mL) for 72 h. Photographs were taken using a phase-contrast microscope, and cell proliferation was assessed by counting with ImageJ. Results: ar-Turmerone treatment significantly promoted neural stem cell proliferation, with a significant increase in cell numbers observed at concentrations ranging from 3.125 to 25 μg/mL, reaching a peak at 6.25 μg/mL. [3] |
| In vivo | Methods: BALB/c nude mice were inoculated with U251 cells in the right axilla. Once the tumor volume reached 40–60 mm3, intraperitoneal injections of ar-Turmerone (40 mg/kg/day) were initiated and continued for 25 days. Results: ar-Turmerone significantly inhibited tumor growth, reduced tumor weight, and downregulated KI67/PCNA expression, with no significant hepatotoxicity or nephrotoxicity. [1] Methods: Male ICR mice received stereotaxic injections of Aβ1-42 into the hippocampus. ar-Turmerone (5, 10 mg/kg) was administered orally via gavage once daily for a total of 28 days, including 21 days prior to and 7 days following Aβ1-42 injection. Results: Oral administration of ar-Turmerone (5, 10 mg/kg) significantly improved learning and memory abilities, enhanced cholinergic function, and reduced hippocampal neuronal apoptosis. [2] Methods: To investigate the effects of ar-Turmerone on neurogenesis, adult male Wistar rats received a single intracerebroventricular injection of 3 mg ar-Turmerone (1 mg/μL dissolved in saline) into the right lateral ventricle, and brain tissue was harvested 7 days post-injection. Results: In vivo, a single intraventricular injection of ar-Turmerone activated endogenous neural stem cells, resulting in a significant increase in the number of DCX? cells in the SVZ region of the rat brain.[3] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | Ethanol : 40 mg/mL (184.91 mM), Sonication is recommended. |
| Keywords | ar-Turmerone | arTurmerone | ar Turmerone |
| Inhibitors Related | Stavudine | Aceglutamide | Urea | Tamoxifen | Cysteamine hydrochloride | Metronidazole | Citric Acid Triammonium | Formamide | Dimethyl phthalate | Alginic acid | Sodium Molybdate | Sildenafil citrate |
| Related Compound Libraries | Traditional Chinese Medicine Monomer Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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