AR453588 hydrochloride NEW
| Price | $1970 | $2580 | $3400 |
| Package | 25mg | 50mg | 100mg |
| Supply Ability: | 10g |
| Update Time: | 2026-04-21 |
Product Details
| Product Name: AR453588 hydrochloride | CAS No.: 1065606-97-4 |
| Supply Ability: 10g | Release date: 2026/04/21 |
Product Introduction
Bioactivity
| Name | AR453588 hydrochloride |
| Description | AR453588 hydrochloride is an orally bioavailable anti-diabetic glucokinase activator (EC50: 42 nM) with anti-hyperglycemic activity. |
| In vivo | AR453588 hydrochloride (3-30 mg/kg; p.o) reduces post-prandial glucose in normal C57BL/6J mice and exhibits anti-hyperglycemic activity in ob/ob mice over a 14-day, once-daily dosing regimen. For AR453588 (10 mg/kg; p.o.), Tmax, AUCinf, Vss, Cmax, and F are 1.0 mL/min/kg, 4.65 h μg/mL, 1.67 μg/mL, and 60.3%, respectively. For AR453588 (1 mg/kg; i.v.), CL, AUCinf, Vss, and t1/2 are 21.6 mL/min/kg, 0.77 h μg/mL, 0.746 L/kg, and 1.28 hours, respectively. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | AR-453588 hydrochloride | AR453588 hydrochloride | AR 453588 Hydrochloride |
| Inhibitors Related | Gcase activator 2 | ARRY-403 | ML251 | PFK-015 | PFKFB3-IN-2 | D-(-)-3-Phosphoglyceric acid disodium | Oxfendazole | AZ PFKFB3 26 | AMG-1694 | RO-28-1675 | Dorzagliatin | PF-04937319 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, USA
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