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Postion:Product Catalog >AS-35
AS-35
  • AS-35

AS-35 NEW

Price $293 $436 $722
Package 1mg 2mg 5mg
Supply Ability: 10g
Update Time: 2026-05-11

Product Details

Product Name: AS-35 CAS No.: 108427-72-1
Purity: 98.72% Supply Ability: 10g
Release date: 2026/05/11

Product Introduction

Bioactivity

NameAS-35
DescriptionAS-35 is an orally effective, potent, and selective antagonist of leukotrienes, antagonizing LTC4-, LTD4-, and LTE4-induced ileum contractions with IC50 values of 8 nM, 4 nM, and 3 nM, respectively. It exhibits antiallergic activities.
In vitroIn the trachea, the drug also antagonized LTD4- and LTE4-induced contraction with IC50 values ??of 10 nM and 20 nM, respectively. In isolated guinea pig preparations, AS-35 antagonized LTC4, LTD4, and LTE4-induced ileal contractions with IC50 values ??of 8 nM, 4 nM, and 3 nM, respectively. AS-35 does not antagonize LTC4-induced tracheal constriction in the presence of L-serine borate [1].
In vivoAS-35 (p.o.) inhibits LTD4-induced increase in vascular permeability in guinea pig skin [1]. Oral administration of AS-35 also antagonized LTD4 as well as antigen-induced LT-mediated bronchoconstriction. AS-35 (0.0375 to 0.3 mg/kg, i.v.) dose-dependently antagonized bronchoconstriction induced by intravenous administration of LTC4 and LTD4 but not histamine-induced bronchoconstriction in anesthetized guinea pigs.[1]
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
KeywordsLTE4 | LTD4 | LTC4 | LeukotrieneReceptor | Leukotriene Receptor | AS-35 | AS35 | AS 35
Inhibitors RelatedMoxilubant HCl | Montelukast sodium | LTB4-IN-1 | L 674573 | Olsalazine disodium | Pirodomast | Pranlukast | Desloratadine | CGP 35949 | ABT-080 | Darbufelone mesylate | Ticolubant
Related Compound LibrariesBioactive Compound Library | Membrane Protein-targeted Compound Library | ReFRAME Related Library | Inhibitor Library | Orally Active Compound Library | Bioactive Compounds Library Max | GPCR Compound Library

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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TargetMol Chemicals Inc.

6YR United StatesUnited States
  • Since: 2011-01-07
  • Address: 36 Washington Street, Wellesley Hill, MA
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