Ascomycin NEW
| Price | $36 | $52 | $63 |
| Package | 5mg | 10mg | 50mg |
| Supply Ability: | 10g |
| Update Time: | 2026-06-02 |
Product Details
| Product Name: Ascomycin | CAS No.: 104987-12-4 |
| Purity: 98.59% | Supply Ability: 10g |
| Release date: 2026/06/02 |
Product Introduction
Bioactivity
| Name | Ascomycin |
| Description | Ascomycin (Immunomycin)(Immunomycin, FR-900520, FK520) is an ethyl analog of tacrolimus (FK506) with strong immunosuppressant properties. |
| In vitro | Intramuscular injection of 3.2 mg/kg Ascomycin significantly prolonged the survival rate of rats with skin transplants. When administered into the rat hippocampus, Ascomycin at concentrations of 50 or 100 μM exhibited anticonvulsant effects against seizures induced by pentylenetetrazol. |
| In vivo | Ascomycin inhibits calcineurin by forming an FKBP12-FK520-calcineurin complex, with an IC50 of 49 nM. Additionally, FK520 accelerates neural regeneration and promotes neurite outgrowth. Ascomycin exhibits antimalarial effects by inhibiting the molecular chaperone activity of a bifunctional protein. Moreover, ascomycin suppresses the in vitro immune response of mixed lymphocytes in mice, with an IC50 of 0.55 nM. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 250 mg/mL (315.65 mM), Sonication is recommended. 10% DMSO+90% Saline : < 10 mg/mL (12.63 mM), Lower concentrations may be soluble, but exact solubility limit is unknown. Ethanol : 39.6 mg/mL (50 mM), Sonication is recommended. 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 10 mg/mL (12.63 mM), Suspension. |
| Keywords | Parasite | macrolide | Inhibitor | inhibit | immunosuppressant | Fungal | FR900520 | FR 900520 | FKBP12 | FKBP | FK-520 | FK506-binding protein | FK 520 | calcineurin phosphatase | Ascomycin | anti-spasmodic | anti-malarial | anti-fungal | Antibiotic |
| Inhibitors Related | Neomycin sulfate | Calcium Propionate | Kanamycin sulfate | Sulfamethoxazole sodium | Terbinafine hydrochloride | Hydroxychloroquine | Benzyl propionate | Metronidazole | 2-Amino-2-methyl-1-propanol | Doxycycline | Penicillin G sodium salt | Fenpyroximate |
| Related Compound Libraries | Anti-Parasitic Compound Library | Bioactive Compound Library | Anti-Fungal Compound Library | Natural Product Library | Microbial Natural Product Library | Antiparasitic Natural Product Library | Natural Product Library for HTS | Lipid Metabolism Compound Library | Immunology/Inflammation Compound Library | Anti-infective Natural Product Library | Bioactive Compounds Library Max | Human Metabolite Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, MA
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