Aspirin NEW
| Price | $46 |
| Package | 500mg |
| Supply Ability: | 10g |
| Update Time: | 2025-04-28 |
Product Details
| Product Name: Aspirin | CAS No.: 50-78-2 |
| Purity: 99.78% | Supply Ability: 10g |
| Release date: 2025/04/28 |
Product Introduction
Bioactivity
| Name | Aspirin |
| Description | Aspirin (Acetylsalicylic Acid) is a COX inhibitor that inhibits COX1 and COX2 (IC50=5/210 μg/mL) with selective, irreversible, and oral activity. Aspirin is also a histone deacetylase inhibitor that up-regulates the cell cycle blocking protein, p21. Aspirin has a variety of activities. Aspirin has anti-inflammatory, antipyretic and analgesic, and antiplatelet aggregation activities. |
| Cell Research | Chondrocytes are isolated from articular cartilage of donors with no articular disease. Unstimulated and interleukin 1 (IL-1) stimulated chondrocytes are used as models to study the effects of drugs on COX-1 and COX-2. Cells are incubated with vehicle or drugs (Asprin); supernatants are removed and the level of prostaglandin E2 (PGE2) in each sample is determined by enzyme immunoassay. IC50s are calculated from the reduction in PGE2 content by different concentrations of the test substance by linear regression analysis[5]. |
| In vitro | METHODS: Colorectal cancer cells SW620, LoVo, RKO and DLD-1 were treated with Aspirin (2 mM) and Cisplatin (5-80 μM) for 48 h. Cell viability was detected by MTT assay. RESULTS: The combination more effectively reduced the viability of colon cancer cells. The combination treatment resulted in a significant decrease in the IC50 value of Cisplatin. [1] METHODS: Osteoblasts MG-63 were treated with Aspirin (1-1000 μM) for 24 h. Cell cycle was detected by Flow cytometry. RESULTS: Aspirin at doses of 1, 10, and 20 μM had no significant effect on the MG-63 cell cycle after 24 h of treatment. However, the percentage of cells in G0/G1 phase was significantly increased at doses of 100 and 1000 μM. [2] |
| In vivo | METHODS: To assay in vivo antitumor activity, Aspirin (100 mg/kg administered by gavage once daily) and Cisplatin (3 mg/kg administered intraperitoneally every three days) were administered to nude mice bearing LoVo xenografts for 18 days. RESULTS: Aspirin and Cisplatin synergistically inhibited the growth of colon cancer grafts in nude mice, and these effects were exerted, at least in part, through modulation of the PI3K-Akt, RAF-MEK-ERK, and NF-κB/COX-2 signaling pathways. [1] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | 10% DMSO+90% Saline : 1.8 mg/mL (9.99 mM), In vivo: Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. H2O : 1.80 mg/mL (10 mM), Sonication and heating are recommended. DMSO : 50 mg/mL (277.53 mM), Sonication is recommended. |
| Keywords | VirusProtease | Virus Protease | prostaglandin synthetase | platelet | p38 MAPK | Nuclear factor-κB | Nuclear factor-kappaB | NF-κB | Mitophagy | Mitochondrial Autophagy | Inhibitor | inhibit | inflammation | fever | Cyclooxygenase | COX-2 | COX-1 | COX | coronary artery | cerebrovascular thrombosis | Caspase | cancer | Autophagy | Aspirin | Apoptosis | Antipyretic effect |
| Inhibitors Related | Stavudine | Phenytoin sodium | Acetaminophen | Sodium 4-phenylbutyrate | Hydroxychloroquine | Guanidine hydrochloride | Taurine | Valproic Acid | Curcumin | Paeonol | Naringin | Gefitinib |
| Related Compound Libraries | Highly Selective Inhibitor Library | Anti-Neurodegenerative Disease Compound Library | Pain-Related Compound Library | Anti-Cancer Clinical Compound Library | Drug Repurposing Compound Library | Inhibitor Library | Anti-Cancer Approved Drug Library | Bitter Compound library | Anti-Aging Compound Library | Anti-virus Traditional Chinese Medicine Monomer Library | Bioactive Compounds Library Max | Anti-Cancer Drug Library |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
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