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Postion:Product Catalog >Biochemical Engineering>Inhibitors>PI3K / Akt / mTOR>Akt inhibitors>AT13148
AT13148
  • AT13148

AT13148 NEW

Price $30 $89 $139
Package 1mg 5mg 10mg
Supply Ability: 10g
Update Time: 2026-04-22

Product Details

Product Name: AT13148 CAS No.: 1056901-62-2
Purity: 99.60% Supply Ability: 10g
Release date: 2026/04/22

Product Introduction

Bioactivity

NameAT13148
DescriptionAT13148 is an oral-active and ATP-competitive, multi-AGC kinase inhibitor for Akt1/2/3, p70S6K, PKA, and ROCKI/II.
Cell ResearchCytotoxicity is determined using a 72 h Alamar Blue assay or a 96 h SRB assay. (Only for Reference)
Kinase AssayIn vitro kinase assays: AT13148 is assayed against 40 kinases and the percentage inhibition at 10 μM of AT13148 is determined. Individual IC50 values are measured for selected kinases using ATP concentrations equivalent to the Km for each enzyme.
In vitroIn PTEN-deficient MES-SA cells, AT13148 was able to inhibit AKT and p70S6K signaling. In cancer cell lines with aberrant PI3K-AKT-mTOR or RAS-RAF pathways (GI50=1.5-3.8 μM), AT13148 was able to inhibit multiple AGC kinases, thereby suppressing cancer cell proliferation.
In vivoIn PTEN-deficient MES-SA cells, AT13148 was able to inhibit AKT and p70S6K signaling. In cancer cell lines with aberrant PI3K-AKT-mTOR or RAS-RAF pathways (GI50=1.5-3.8 μM), AT13148 was able to inhibit multiple AGC kinases, thereby suppressing cancer cell proliferation.
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
Solubility InformationH2O : < 1 mg/mL (insoluble or slightly soluble)
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (6.37 mM), Sonication is recommended.
Ethanol : < 1 mg/mL (insoluble or slightly soluble)
DMSO : 58 mg/mL (184.84 mM), Sonication is recommended.
KeywordsSGK3 | S6Kinase | S6K | S6 Kinase | RSK1 | ROK | ROCK2 | ROCK1 | ROCK | Ribosomal S6 Kinase (RSK) | Rho-kinase | Rho-associated protein kinase | Rho-associated kinase | Protein kinase B | Protein kinase A | PKB | PKA | p70 S6K | Inhibitor | inhibit | AT-13148 | AT13148 | AT 13148 | Akt3 | Akt2 | Akt1 | Akt
Inhibitors RelatedUndecane | Aceglutamide | Musk ketone | Stearamide | Bisphenol A | Rhamnose monohydrate | Hyaluronic acid | Ethyl linoleate | Methyl eugenol | Chloramphenicol | 2,3-Butanediol | Isovaleric acid
Related Compound LibrariesBioactive Compound Library | Pain-Related Compound Library | Tyrosine Kinase Inhibitor Library | Anti-Cancer Clinical Compound Library | Drug Repurposing Compound Library | Inhibitor Library | Anti-Aging Compound Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | TGF-beta/Smad Compound Library | Anti-Cancer Drug Library | Anti-Cancer Active Compound Library

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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6YR United StatesUnited States
  • Since: 2011-01-07
  • Address: 36 Washington Street, Wellesley Hill, MA
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