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Postion:Product Catalog >Biochemical Engineering>Inhibitors>Transmembrane Transporters>CFTR inhibitors>Ataluren
Ataluren
  • Ataluren

Ataluren NEW

Price Get Latest Price
Package 25KG
Min. Order: 1KG
Supply Ability: 5000kgs
Update Time: 2026-03-27

Product Details

Product Name: Ataluren CAS No.: 775304-57-9
Min. Order: 1KG Purity: 98% HPLC
Supply Ability: 5000kgs Release date: 2026/03/27

Ataluren activity, optimized using a reporter gene containing a nonsense enzyme, promotes dystrophin production in primary myocytes of human and mdx mice expressing a nonsense allele of dystrophin, and following drug exposure 2 - Rescue of striated muscle function in mdx mice over 8 weeks. Ataluren (PTC124) was tolerated in animals in plasma exposures substantially in excess of those required for nonsense inhibition[2]. To induce nonsense inhibition and increase PPT1 enzyme activity, 2-week-old male Cln1R151X mice were given the read-through drug Ataluren (PTC124) by intraperitoneal (ip) injection. In the proof-of-principle study, these treatments were performed four times daily for 2 consecutive days. Ataluren (PTC124) increased PPT1 enzyme activity (P = 0.0001 by unpaired t-test) and protein levels (P = 0.0014 by unpaired t-test) in liver at 10 mg/kg, but did not increase PPT1 enzyme activity or Protein levels in cortex. This tissue-specific effect may be due to the inability of Ataluren (PTC124) to disrupt the blood-brain barrier (BBB), which reduces the bioavailability of Ataluren (PTC124) in the brain and prevents Ataluren (PTC124) from reaching effective concentrations within the therapeutic window


Company Profile Introduction

Shandong Perfect Biotechnology Co.Ltd founded in 2014, the company is a supplier and service provider of pharmaceutical and chemical raw materials and animal husbandry and animal health industries. The company is located in Jinan, a beautiful spring city, where the transportation is developed, the logistics is convenient, and the industrial supporting resources are abundant, which provides a stable foundation for the promotion of the company's products. In 2018, the company initiated the establishment of Shandong Qinshi Biotechnology Co., Ltd. to serve domestic veterinary drug preparation companies, and Qinshi successfully passed the national veterinary drug GSP certification on September 10, 2018. In 2020, the company passed the ISO quality management system certification. As a result, the company has formed a pattern in which Jihao Company exports pharmaceutical and chemical raw materials and intermediates, and Qinshi Company serves domestic animal protection enterprises as veterinary raw materials. In this way, it can be more stable and standardized to meet the needs of different customers at home and abroad. At present, the company cooperates closely with several university research institutes and high-tech pharmaceutical industry companies, strictly controls each link from product research and development, production, sales, and dares to innovate, and continuously improves product quality and competitive advantages to promote the company's benign and stable development. We continue to develop superior varieties with our partners, and provide customers with products that meet customer requirements in accordance with CP, JP, BP, USP, EP and other standards, making our products and services a close and stable partner for customers. The company pays equal attention to the development of both international and domestic markets, and a complete sales team can serve its partners wholeheartedly. We provide products and services to our customer

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  • Since: 2014-09-09
  • Address: No.28 Hua Long Road,Ji Nan City,China
INQUIRY
徐炳江
+86-13153181156
sales@sdperfect.com
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