Product Details
| Product Name:
AZD-5672 |
CAS No.:
780750-65-4 |
| Purity:
98.10% |
Supply Ability:
10g |
| Release date:
2026/07/27 |
Product Introduction
Bioactivity
| Name | AZD-5672 |
| Description | AZD-5672 is an antagonist of CCR5 with an IC50 of 0.32 nM. AZD-5672 inhibits hERG cardiac ion channel binding and P-gp-mediated digoxin transport with IC50s of 7.3 μM and 32 μM. AZD-5672 can be used in studies about rheumatoid arthritis. |
| In vitro | In Caco-2 cells, AZD-5672 (0-100 μM) inhibits P-gp-mediated digoxin transport in a concentration-dependent manner[1]. |
| In vivo | AZD-5672 (1-2 mg/kg; i.v) shows moderate bioavailability with CI, Vss and t1/2 of 28 mL/min/kg, 5.3 L/kg, and 2.6 h in rats while 18 mL/min/kg, 5.7 L/kg, and 3.9 h in dogs[3]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 30 mg/mL (47.41 mM), Sonication and heating to 60℃ are recommended.
|
| Keywords | P-gp | Pgp | hERG | CCR5 | AZD-5672 |
| Inhibitors Related | Carbamazepine | Uridine 5'-monophosphate disodium salt | 1,8-Cineole | Tetraethylammonium bromide | Tetraethylammonium chloride | Cesium chloride | Chenodeoxycholic acid | 4-Aminopyridine | Pirfenidone | 2,2,2-Trichloroethanol | Nifedipine | Indapamide |
| Related Compound Libraries | Bioactive Compound Library | Membrane Protein-targeted Compound Library | Tyrosine Kinase Inhibitor Library | Anti-Cancer Clinical Compound Library | Drug Repurposing Compound Library | Inhibitor Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | Fluorochemical Library | GPCR Compound Library | Ion Channel Targeted Library | Anti-Cancer Drug Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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