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Postion:Product Catalog >BAY-293
BAY-293
  • BAY-293

BAY-293 NEW

Price $48 $113 $197
Package 1mg 5mg 10mg
Supply Ability: 10g
Update Time: 2026-06-02

Product Details

Product Name: BAY-293 CAS No.: 2244904-70-7
Purity: 97.16% Supply Ability: 10g
Release date: 2026/06/02

Product Introduction

Bioactivity

NameBAY-293
DescriptionBAY-293 is a potent, cell-active SOS1 inhibitor that disrupts the KRAS-SOS1 interaction (IC50: 21 nM).
In vitroBAY-293 is a SOS1 inhibitor that disrupts the KRAS-SOS1 interaction with IC50 of 21 nM and displays no significant activity against KRAS WT-CRAF RBD, CDC42 and EGFR (>20 uM). It inhibits the activation of RAS in HeLa cells with IC50 of 410 nM, efficiently inhibits pERK levels in K562 cells after incubation for 60 min without affecting total protein levels of ERK (IC50: 180 nM). BAY-293 shows antiproliferative activity against wild-type KRAS cell lines (K562, MOLM-13; IC50~1 uM) and cell lines with KRASG12C mutation (NCI-H358, Calu-; IC50~3 uM) by preventing the formation of the KRAS-SOS1 complex.
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
Solubility Information10% DMSO+90% Saline : < 10 mg/mL (22.29 mM), Lower concentrations may be soluble, but exact solubility limit is unknown.
DMSO : 250 mg/mL (557.31 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 10 mg/mL (22.29 mM), Solution.
KeywordsSOS1 | Ras | Inhibitor | inhibit | BAY-293 | BAY293 | BAY 293
Inhibitors RelatedAdagrasib | Regorafenib monohydrate | RMC-9805 | Vemurafenib | Sorafenib | (R)-Naproxen | Ketoconazole | MRTX1133 | Regorafenib | Dabrafenib | Sotorasib | Daraxonrasib
Related Compound LibrariesBioactive Compound Library | Pain-Related Compound Library | Membrane Protein-targeted Compound Library | HIF-1 Signaling Pathway Compound Library | Kinase Inhibitor Library | Glutamine Metabolism Compound Library | Inhibitor Library | NO PAINS Compound Library | Stem Cell Differentiation Compound Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | GPCR Compound Library

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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TargetMol Chemicals Inc.

6YR United StatesUnited States
  • Since: 2011-01-07
  • Address: 36 Washington Street, Wellesley Hill, MA
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