BAY-524 NEW
| Price | $93 | $196 | $331 |
| Package | 1mg | 5mg | 10mg |
| Supply Ability: | 10g |
| Update Time: | 2026-05-15 |
Product Details
| Product Name: BAY-524 | CAS No.: 1445830-39-6 |
| Purity: 98.68% | Supply Ability: 10g |
| Release date: 2026/05/15 |
Product Introduction
Bioactivity
| Name | BAY-524 |
| Description | BAY-524 belongs to small molecule inhibitors and is a Bub1 kinase inhibitor (IC50 = 450 nM under 2 mM ATP conditions) with good cell permeability and selectivity. This compound demonstrates antitumor potential and can be used in research on combination anticancer therapy. |
| In vitro | Methods: Human Bub1 recombinant catalytic domain and various cell models were treated with different concentrations of BAY-524 (0-30 μM) for different durations (1-48 h) to detect kinase activity, Sgo1/Sgo2 localization, chromatid cohesion, chromosomal passenger complex (CPC) localization and activity, centromere binding, spindle assembly checkpoint (SAC) signaling, and cellular sensitivity to low-dose paclitaxel in combination. Results: BAY-524 inhibited the human Bub1 recombinant catalytic domain (IC50 = 450 nM) and specifically inhibited Bub1 kinase; affected Sgo1/Sgo2 localization and chromatid cohesion; influenced CPC localization and activity; produced additive effects on centromere binding; had a minor effect on SAC signaling; and sensitized cells to low-dose paclitaxel. [1] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 150 mg/mL (310.89 mM), Sonication is recommended. 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 5 mg/mL (10.36 mM), Sonication is recommended. |
| Keywords | Shugoshin proteins (Sgo1and Sgo2) | recombinant catalytic domain | Inhibitor | inhibit | human Bub1, 2 mM ATP | BUB1 kinase | BAY-524 | BAY524 | BAY 524 | anti-cancer |
| Inhibitors Related | Culmerciclib | Fasudil | Bicyclol | Piceatannol | Chymotrypsin | Fasudil hydrochloride | Camostat mesylate | 6-(Dimethylamino)purine | FOY 251 | BMT-124110 Formate | Benzamidine hydrochloride | Cetraxate hydrochloride |
| Related Compound Libraries | NO PAINS Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, MA
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