BChE-IN-4 NEW
| Price | $1520 | $1980 | $2500 |
| Package | 25mg | 50mg | 100mg |
| Supply Ability: | 10g |
| Update Time: | 2026-04-21 |
Product Details
| Product Name: BChE-IN-4 | CAS No.: 2304818-41-3 |
| Supply Ability: 10g | Release date: 2026/04/21 |
Product Introduction
Bioactivity
| Name | BChE-IN-4 |
| Description | BChE-IN-4 is a highly potent inhibitor of the enzyme butyrylcholinesterase, capable of crossing the blood-brain barrier. It effectively reduces learning and memory impairments resulting from a deficiency in cholinergic activity in a mouse model. BChE-IN-4 holds promise for further investigation in the field of Alzheimer's disease research [1]. |
| In vivo | BChE-IN-4 (compound 1) administered at doses of 10, 20, and 30 mg/kg effectively mitigates learning and memory impairments associated with cholinergic deficits in an Alzheimer's disease (AD) mouse model, without inducing adverse motor effects at 30 mg/kg. Studies on adult male Albino Swiss CD-1 mice with scopolamine-induced memory impairments revealed that BChE-IN-4 significantly enhances step-through latencies, indicating memory improvement. Additionally, in C57BL/6J mice (18-22 g), a 30 mg/kg dosage enhanced long-term memory retrieval by day 12 in the Barnes maze task, though it did not initially improve learning abilities or short-term memory retrieval by day 5. Further examination at a 30 mg/kg dosage, suspended in 1% Tween 80, confirmed that BChE-IN-4 does not affect locomotor activity nor cause motor deficits in rotarod tests, affirming its safety and efficacy in improving cognitive functions without impairing motor skills. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Inhibitors Related | Uridine 5'-monophosphate disodium salt | Ethyl (triphenylphosphoranylidene) acetate | Methylene Violet 3RAX | 4-Methylbenzylidene camphor | Diethyltoluamide | Pralidoxime Iodide | Propoxur | Dimethyl sulfoxide | Coumaran | (±)-Dihydroactinidiolide | Methyl tridecanoate | Trimethylammonium chloride |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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