Berberine hydrochloride has long been used in clinical practice as a heat clearing, detoxifying, and antibacterial drug. Commonly used to treat bacterial dysentery, acute gastroenteritis, chronic cholecystitis, as well as conjunctivitis, purulent otitis media and other diseases, all have significant therapeutic effects. Berberine hydrochloride is an isoquinoline alkaloid found in many plants, including 4 families and 10 genera of Berberidaceae. Berberine can precipitate yellow needle shaped crystals from ether.