BGC 20-761 NEW
| Price | $838 |
| Package | 10mg |
| Supply Ability: | 10g |
| Update Time: | 2026-05-11 |
Product Details
| Product Name: BGC 20-761 | CAS No.: 17375-63-2 |
| Supply Ability: 10g | Release date: 2026/05/11 |
Product Introduction
Bioactivity
| Name | BGC 20-761 |
| Description | BGC20-761 is a selective 5-HT6 and dopamine receptor antagonist (human receptor K i values: 5-HT6 (20 nM), 5-HT2A (69 nM), D2 (140 nM)), and a tryptamine analog with a high affinity for 5-HT(6) receptors, that can enhance long-term memory, with potential utility as an antipsychotic agent [1]. |
| In vitro | BGC20-761 is a highly efficient and selective 5-HT6 receptor antagonist; rat K i values for other rats receptors: 5-HT2A (470 nM), 5-HT2C (675 nM), D2, D3, D4, DAT and SERT (>10,000 nM) [1]. |
| In vivo | BGC20-761 effectively improves memory consolidation and mitigates scopolamine-induced deficits in both social and visuospatial memory tasks through a 5-HT6 receptor-mediated mechanism. Specifically, while BGC20-761 at doses of 2.5 mg/kg, 5 mg/kg, and 10 mg/kg, administered intraperitoneally (i.p.), does not alter social recognition in young rats on its own, it significantly counteracts the social recognition impairment caused by Scopolamine (0.4 mg/kg i.p.) in a dose-dependent manner at 5 mg/kg and 10 mg/kg. This study utilized forty-two 8-week-old male Long Evans rats and twelve 4-week-old male Sprague Dawley rats. Although the administration of BGC20-761 alone showed no notable difference in social recognition when compared to saline-treated controls, doses of 5 mg/kg and 10 mg/kg effectively reversed the deficit in social recognition induced by Scopolamine when administered immediately after the training session for the social recognition test. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | BGC 20-761 | BGC 20761 | BGC 20 761 |
| Inhibitors Related | Alverine citrate | Dapoxetine hydrochloride | Cefaclor monohydrate | Hexamethonium Bromide | Octopamine hydrochloride | 1,8-Cineole | L-DOPA | Creatine | Oxolinic acid | Mianserin hydrochloride | Trazodone hydrochloride | Cinchonidine |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, MA
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