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Postion:Product Catalog >Biochemical Engineering>Biochemical Reagents>Agonist Inhibitors>BHPI
BHPI
  • BHPI

BHPI NEW

Price $596
Package 50mg
Supply Ability: 10g
Update Time: 2026-05-26

Product Details

Product Name: BHPI CAS No.: 56632-39-4
Purity: 99.85% Supply Ability: 10g
Release date: 2026/05/26

Product Introduction

Bioactivity

NameBHPI
DescriptionBHPI is a potent inhibitor of nuclear estrogen receptor ERα–regulated gene expression that induces sustained ERα-dependent activation of the endoplasmic reticulum stress sensor and unfolded protein response, leading to persistent inhibition of protein synthesis, and in ERα-positive cancer cells it hyperactivates plasma membrane PLCγ to generate IP3, deplete ER calcium stores via IP3R channels, and convert the normally protective UPR into a toxic response, making BHPI a valuable probe for estrogen signaling and ER stress–based cancer research.
In vitroIn cellular assays, BHPI inhibited the proliferation of ERα-positive breast, endometrial, and ovarian cancer cells at concentrations between 100 and 1000 nM. It maintained activity (25 nM) in antiestrogen-resistant cell lines harboring ERα mutations (Y537S, D538G) by triggering UPR hyperactivation, protein synthesis inhibition, and apoptosis [1].
In vivoIn MCF-7 breast cancer xenograft models, intraperitoneal (i.p.) administration of BHPI (10-15 mg/kg) resulted in tumor regression. When administered daily for 10 days or every other day, tumor regression was observed in 48 out of 52 treated tumors. This effect is attributed to the sustained activation of UPR stress within the tumor tissue [1].
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
Solubility Information10% DMSO+40% PEG300+5% Tween-80+45% Saline : 4 mg/mL (12.07 mM), Sonication is recommended.
DMSO : 100 mg/mL (301.79 mM), Sonication is recommended.
KeywordsBHPI
Inhibitors RelatedTamoxifen | Mifepristone | Estradiol | Astragaloside IV | Estradiol benzoate | Bisphenol Z | 17α-Hydroxyprogesterone | Ethisterone | Alpha-Estradiol | Ferrous Bisglycinate | Megestrol acetate | Hinokitiol

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

Recommended supplier

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2026-05-27
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TargetMol Chemicals Inc.

4YR United StatesUnited States
  • Since: 2011-01-07
  • Address: 36 Washington Street, Wellesley Hill, USA
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