Product Details
| Product Name:
BI-0252 |
CAS No.:
1818291-27-8 |
| Supply Ability:
10g |
Release date:
2026/05/11 |
Product Introduction
Bioactivity
| Name | BI-0252 |
| Description | BI-0252 is an inhibitor of MDM2-p53 (IC50:4 nM). BI-0252 can induce tumor regressions in all animals of a mouse SJSA-1 xenograft. And it concomitant induction of the tumor protein p53 (TP53) target genes and markers of apoptosis. |
| In vivo | BI-0252 has high po in vivo exposure and good cellular potency[1]. BI-0252 (orally; 25 mg/kg/day for 13 days and 100 mg/kg for 24 h) leads to time-dependent mRNA induction of TP53 target genes including CDKN1a, MDM2, and BBC3[1]. BI-0252 (iv and po; an iv dose of 5 mg/kg and a po dose of 50 mg/kg) showes low clearance in vivo after iv administration and high clearance after po administration. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | MDM2-p53 | BI-0252 | BI0252 | BI 0252 |
| Inhibitors Related | 10-Hydroxydecanoic Acid | Flubendazole | Diuron | Gallium maltolate | Yucasin | D-(-)-3-Phosphoglyceric acid disodium | EN219 | Thiabendazole | Triglycidyl isocyanurate | Indole-3-carbinol | Methyl methanesulfonate | (E/Z)-10-Hydroxy-2-decenoic acid |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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