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Postion:Product Catalog >BI8622
BI8622
  • BI8622

BI8622 NEW

Price $297 $987 $1360
Package 5mg 25mg 50mg
Supply Ability: 10g
Update Time: 2025-08-22

Product Details

Product Name: BI8622 CAS No.: 1875036-74-0
Purity: 98.28% Supply Ability: 10g
Release date: 2025/08/22

Product Introduction

Bioactivity

NameBI8622
DescriptionBI8622 is a ubiquitin ligase HUWE1-specific antagonist that restores the level of RP2 mutants in retinal cell lines and inhibits the activation of NLRP3, NLRC4, and AIM2 inflammatory vesicles in cells.
In vitroBI8622 is a specific inhibitor of HUWE1 ubiquitin ligase with an IC50 of 3.1 μM.It inhibited ubiquitination of MCL1 in HeLa cells by ectopic expression of HUWE1, with an IC50 value of 6.8 μM.In addition, BI8622 inhibited clonogenic formation of Ls174T cells with an estimated IC50 of 8.4 μM. BI8622 (10 μM, 1-4 days treatment) delayed the progression of Ls174T cells at all stages of the cell cycle, with the most pronounced inhibitory effect in the G1 phase.BI8622 (0-50 μM, 16 hours treatment) prevented the degradation of MCL1 in HeLa cells under UV irradiation by inhibiting HUWE1. It also inhibited MYC-dependent transcriptional activation in colorectal cancer cells. [1]
Storagekeep away from direct sunlight,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility InformationDMSO : 100 mg/mL (234.46 mM), Sonication is recommended.
KeywordsRNASynthesis | RNA Synthesis | HUWE1 | DNASynthesis | DNA/RNA Synthesis | DNA Synthesis | BI-8622 | BI8622
Inhibitors Related5-Fluorouracil | Procaine | Rifaximin | Ribavirin | Guanidine hydrochloride | Trimethoprim | N-Nitrosodiethylamine | Cytarabine | Acyclovir | Thymidine | Temozolomide | Folic acid

Company Profile Introduction

TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds. 170+ Compound Libraries, 10000+ Noval Small Molecucles,16000+ Nature Compounds TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.

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2YR United StatesUnited States
  • Since: 2011-01-07
  • Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
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