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Postion:Product Catalog >Bimosiamose
Bimosiamose
  • Bimosiamose

Bimosiamose NEW

Price $83 Get Latest Price
Package 1mg 5mg
Supply Ability: 10g
Update Time: 2026-04-21

Product Details

Product Name: Bimosiamose CAS No.: 187269-40-5
Supply Ability: 10g Release date: 2026/04/21

Product Introduction

Bioactivity

NameBimosiamose
DescriptionBimosiamose has anti-inflammatory effects[1]. Bimosiamose (TBC-1269) is a nonoligosaccharide pan-selectin antagonist with IC50s of 88 μM, 20 μM, and 86 μM for E-selectin, L-selectin, and P-selectin respectively.
In vitroBimosiamose (TBC-1269) effectively inhibits neutrophil recruitment to inflammation sites by obstructing the initial rolling phase of recruitment, without exhibiting cytotoxic effects on neutrophils.
In vivoBimosiamose (TBC-1269; 25 mg/kg; intravenous injection; Sprague-Dawley rats) treatment significantly increases survival, ameliorates neutrophil migration by 81%, and improves histologic damage scores[1]. The best overall survival rate of 70% is observed when administered 15 minutes before reperfusion, with a marked decrease in liver enzyme levels at 6 hours after reperfusion.
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
Solubility Information10% DMSO+40% PEG300+5% Tween-80+45% Saline : 3.3 mg/mL (3.82 mM), Sonication is recommended.
0.1 M NaOH : 25 mg/mL (28.97 mM), when pH is adjusted to 10 with NaOH. Sonication is recommended.
DMSO : 125 mg/mL (144.86 mM), Sonication is recommended.
KeywordsTBC1269 | TBC 1269 | P-selectin | L-selectin | E-selectin | Bimosiamose
Inhibitors RelatedK34c hydrochloride | Cucurbitacin B | Tirofiban hydrochloride monohydrate | (R)-Leucic acid | Lifitegrast | Cyclo(-RGDfK) | ADH-503 | Elsibucol | CLT-28643 | Bestatin hydrochloride | Gantofiban | 2-hydroxy Flutamide

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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4YR United StatesUnited States
  • Since: 2011-01-07
  • Address: 36 Washington Street, Wellesley Hill, USA
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