Biricodar NEW
| Price | $1820 | $2380 | $3100 |
| Package | 25mg | 50mg | 100mg |
| Supply Ability: | 10g |
| Update Time: | 2025-07-17 |
Product Details
| Product Name: Biricodar | CAS No.: 159997-94-1 |
| Supply Ability: 10g | Release date: 2025/07/17 |
Product Introduction
Bioactivity
| Name | Biricodar |
| Description | Biricodar is a P-glycoprotein and MRP-1 modulator. |
| In vitro | Biricodar demonstrates activity against P-glycoprotein (Pgp) and MRP-1 by increasing drug uptake and retention, reversing drug resistance mediated by wild-type BCRP (BCRPR482), and enhancing uptake, retention, and cytotoxicity in HL60/Adr (MRP-1) and 8226/MR20 cells (BCRP(R482)), while having minimal effect on MCF7 AdVP3000 cells (BCRP(R482T))[1]. It effectively inhibits photoaffinity labeling of P-glycoprotein by [3H]azidopine or [125I]iodoaryl azido-prazosin, with EC50 values of 0.75 and 0.55 μM[3]. In 8226/Dox6 cells (Pgp), biricodar enhances mitoxantrone and daunorubicin uptake by 55% and 100%, respectively, retention by 100% and 60%, respectively, and cytotoxicity by 3.1- and 6.9-fold, respectively. VX-710, a non-macrocyclic pipecolinate derivative that binds the FK506 receptor protein, has been shown to restore sensitivity in a range of multidrug-resistant cells, including myeloma, melanoma, carcinoma, and leukemia[2]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | VX710 | VX 710 | Biricodar |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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- Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
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