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Postion:Product Catalog >Bixin
Bixin
  • Bixin

Bixin NEW

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Package 1removed
Supply Ability: 10g
Update Time: 2026-05-11

Product Details

Product Name: Bixin CAS No.: 6983-79-5
Purity: 99.84% Supply Ability: 10g
Release date: 2026/05/11

Product Introduction

Bioactivity

NameBixin
DescriptionBixin is an orally active carotenoid that modulates TLR4/NF-κB, Nrf2, and ROS to mitigate high-fat diet-induced cardiac injury in mice and induces apoptosis in A549, HeLa, and MCF-7 cells.
In vitroBixin (20-80 μM, 24 hours) not only ameliorated LPS-induced cellular fibrosis in H9C2 cells without cytotoxicity, but also alleviated inflammatory responses by inactivating the TLR4/NF-κB pathway and suppressed LPS-mediated ROS generation through activating the Nrf2 pathway [1]. Bixin (0-500 μM, 48 hours) exhibited anti-proliferative effects on three tumor cell lines: Human lung cancer (A549), cervical cancer (HeLa), and breast cancer (MCF-7) [2].
In vivoBixin (50-200 mg/kg, orally administered once daily for 14 weeks) alleviates systemic inflammatory responses in a high-fat diet-induced mouse model by inhibiting the activation of the TLR4/NF-κB signaling pathway and reducing pro-inflammatory cytokine secretion. It also decreases ROS production through activation of the Nrf2 pathway while effectively ameliorating systemic metabolic disorder in mice [1].
Storagekeep away from direct sunlight,keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility InformationDMSO : 5.50 mg/mL (13.94 mM), Sonication is recommended.
KeywordsROS generation | Bixin
Inhibitors RelatedEthoxyquin | Kaolin | Stavudine | Aceglutamide | Allopurinol | Urea | Hydroxychloroquine | Metronidazole | Ethyl linoleate | D-Psicose | Formamide | Alginic acid
Related Compound LibrariesNF-κB Signaling Compound Library | Bioactive Compound Library | Traditional Chinese Medicine Monomer Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | Anti-Cancer Compound Library | Transcription Factor-Targeted Compound Library

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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4YR United StatesUnited States
  • Since: 2011-01-07
  • Address: 36 Washington Street, Wellesley Hill, USA
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