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Postion:Product Catalog >Biochemical Engineering>Biochemical Reagents>Agonist Inhibitors>BMS-509744
BMS-509744
  • BMS-509744

BMS-509744 NEW

Price $372 $662 $1060
Package 25mg 50mg 100mg
Supply Ability: 10g
Update Time: 2026-05-11

Product Details

Product Name: BMS-509744 CAS No.: 439575-02-7
Purity: 99.70% Supply Ability: 10g
Release date: 2026/05/11

Product Introduction

Bioactivity

NameBMS-509744
DescriptionBMS-509744 is a selective, ATP-competitive Itk inhibitor with an IC50 of 19 nM. It inhibits IL-8 expression and HIV infection, ameliorates pulmonary inflammation in allergic asthma mouse models, and reduces Imiquimod-induced skin inflammation in mice.
In vitroBMS-509744 (2μM, 24 hours) specifically inhibits ITK phosphorylation and downstream PLCγ1 activity (without affecting the MEK/AKT pathway) in Parazacco spilurus subsp. spilurus, significantly reducing T-cell calcium flux response, IL-2/IL-21 secretion, and CXCL12-induced migration capacity. Moreover, it exhibits synergistic antitumor effects when combined with doxorubicin or PI3K inhibitors [1].
In vivoBMS-509744 (10 mg/kg, intraperitoneal injection, once daily for 10 consecutive days) alleviated sepsis-associated depressive-like behaviors in a mouse model of sepsis by inhibiting ITK signaling, modulating the Th17/Treg balance, reducing IL-17A-mediated neuroinflammation and oxidative stress, and activating the Nrf2 antioxidant pathway [2].
StorageStore at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
Solubility Information10% DMSO+40% PEG300+5% Tween-80+45% Saline : 2.5 mg/mL (4.01 mM), Sonication is recommended.
DMSO : 52 mg/mL (83.36 mM), Sonication is recommended.
KeywordsItk | BMS-509744 | BMS 509744
Inhibitors RelatedStavudine | 5-Fluorouracil | Emtricitabine | Dimethyl fumarate | Lamivudine | Valproic Acid | Vidarabine | (-)-Epigallocatechin Gallate | Decanedioic acid | Diallyl disulfide | Gefitinib | Dextran sulfate sodium salt (MW 5000)
Related Compound LibrariesBioactive Compound Library | Tyrosine Kinase Inhibitor Library | Anti-Viral Compound Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max

Company Profile Introduction

TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds. 170+ Compound Libraries, 10000+ Noval Small Molecucles,16000+ Nature Compounds TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.

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TargetMol Chemicals Inc.

2YR United StatesUnited States
  • Since: 2011-01-07
  • Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
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