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Postion:Product Catalog >BMS493
BMS493
  • BMS493

BMS493 NEW

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Package 1removed
Supply Ability: 10g
Update Time: 2026-06-02

Product Details

Product Name: BMS493 CAS No.: 215030-90-3
Purity: 100% Supply Ability: 10g
Release date: 2026/06/02

Product Introduction

Bioactivity

NameBMS493
DescriptionBMS493 is an inverse agonist of the pan-retinoic acid receptor (RAR) that inhibits retinoic acid-induced differentiation, enhances the interaction of nuclear co-inhibitors with RARs, attenuates RA signaling, potentiates TPP-induced toxicity, and inhibits the increase in phospholipase A2 activity.
In vitroCells treated with BMS 493 (100 nM; 6 days) showed a twofold increase in the number of ALDHhi cells available for transplantation compared to untreated controls. Newly expanded ALDHhi cells exhibited increased numbers of CD34 and CD133-positive cells, along with a reduction in CD38 expression[1].
In vivoIn contrast to freshly isolated ALDHhi cells, 6-day expansion with or without BMS 493 generated progeny that were unable to reduce hyperglycemia after iPan transplantation into STZ-treated NOD/SCID mice[1].
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information10% DMSO+40% PEG300+5% Tween 80+45% Saline : 5.5 mg/mL (13.6 mM), Suspension.
10% DMSO+90% Saline : < 5.5 mg/mL (13.6 mM), Lower concentrations may be soluble, but exact solubility limit is unknown.
DMSO : 55 mg/mL (135.97 mM), Sonication is recommended.
KeywordsRetinoidReceptor | Retinoid Receptor | RAR | phospholipase A2 | BMS493 | BMS 493
Inhibitors RelatedNeomycin sulfate | Isotretinoin | Levamisole hydrochloride | 1,3,5-Triisopropylbenzene | Retinoic acid | Difluprednate | trans-Benzylideneacetone | Indomethacin | 2,4-Di-tert-butylphenol | Lansoprazole | Magnolol | Magnesium sulfate
Related Compound LibrariesNuclear Receptor Compound Library | Bioactive Compound Library | Bioactive Compounds Library Max

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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Product name Price   Suppliers Update time
VIP6Y
TargetMol Chemicals Inc.
2026-06-02

TargetMol Chemicals Inc.

4YR United StatesUnited States
  • Since: 2011-01-07
  • Address: 36 Washington Street, Wellesley Hill, USA
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