Product Details
| Product Name:
BMVC |
CAS No.:
627810-06-4 |
| Supply Ability:
10g |
Release date:
2025/08/23 |
Product Introduction
Bioactivity
| Name | BMVC |
| Description | BMVC is a potent G-quadruplex (G4) stabilizer and a selective telomerase inhibitor (IC50: ~0.2 μM) with anticancer activities, and it also inhibits Taq DNA polymerase (IC50: ~2.5 μM). |
| In vitro | BMVC (0.5 μM; 0-18 days; H1299 cells) treatment significantly increases the percentage of sub-G1-phase cells after 18 days, leading to cessation of cell growth and cell death through apoptosis. Long-term BMVC treatment induces senescence, accompanied by progressive telomere shortening and DNA damage foci detection, indicating telomere uncapping [1]. |
| In vivo | The treatment of BMVC (1 mg/kg; i.p.; every 3 day; BALB/cAnN.Cg-Foxn1nu/CrlNarl mice) delays tumorigenic potential of cancer cells in vivo [1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | Telomerase | G-quadruplex | BMVC |
| Inhibitors Related | Cyclogalegenin | TMPyP4 tosylate | BIBR 1532 | Cycloastragenol | Braco-19 trihydrochloride | Costunolide | RHPS4 | Braco-19 | Ceramides Mixture | L-778123 hydrochloride | MST-312 | Adefovir |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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