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Postion:Product Catalog >Biologics>Biochemical Reagents>Antagonist>BN201
BN201
  • BN201

BN201 NEW

Price $1520 $1980 $2500
Package 25mg 50mg 100mg
Supply Ability: 10g
Update Time: 2025-06-07

Product Details

Product Name: BN201 CAS No.: 1361200-34-1
Purity: 99.73% Supply Ability: 10g
Release date: 2025/06/07

Product Introduction

Bioactivity

NameBN201
DescriptionBN201 (OCS-05) is a drug with neuroprotective and myelin repair effects, which acts mainly by activating serum glucocorticoid kinase-2 (SGK2), which in turn activates the FOXO3 pathway to promote neuronal survival and myelin repair. It is mainly used for the treatment of inflammatory neurological diseases such as multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE).BN201 is able to regulate multiple kinases in the insulin growth factor 1 (IGF1) pathway and cross the blood-brain barrier.
In vitroMethods: RN22 cells were treated with BN201 (1-10-50 ng/ml or 1-10 μg/ml, 24 hours). Human SH-SY5Y neuroblastoma cells treated with BN201 (0.03, 0.1, 0.5, 1, 3, 5, 10, 20 and 100 μM) were treated with retinoic acid (10 μM, 6 days) and MPP+ (100 μM) or H2O2 (100 μM) were added 30 minutes later. Cell viability was measured by MTT assay. Results: BN201 had the strongest activity in protecting SH-SY5Y and RN22 cells from oxidative stress. [1]
In vivoMethods: Female C57BL/6 mice immunized with MOG35-55 were treated with BN201 (12.5, 25, 50, 100 mg/kg, intraperitoneally, for 30 days) to evaluate its effect in protecting neurons and myelin-producing cells in vivo. Results: BN201-treated mice had less axonal and neuronal loss in the spinal cord and optic nerves. [1]
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
KeywordsBN-201 | BN201
Inhibitors RelatedAT13148 | URMC-099 | GSK 650394 | Ro-3306 | SGK1-IN-4 | EMD638683 | SI-113 | LOM612 | Broussochalcone A | Pinostrobin | CKI-7 | BRD7389

Company Profile Introduction

TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds. 170+ Compound Libraries, 10000+ Noval Small Molecucles,16000+ Nature Compounds TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.

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  • Since: 2011-01-07
  • Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
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